Periodic Reporting for period 1 - ENGAGE (ENGineering extracellular matrix-based de novo proteins with high Affinity to Growth factors for Enhancing bone regeneration)
Reporting period: 2019-10-01 to 2020-09-30
Therefore, alternatives to BMP-2 are important for the society because they might be used to reduce or shorten the time recovery of patients that require a biomaterial implantation after bone fracture.
The overall objective of ENGAGE project is to computationally design a synthetic protein that will substitute BMP-2 and stimulate the same activity but with higher stability. Then, less amounts of the designed protein will be required for implantation, which is expected to reduce the undesired side effects associated to BMP-2.