Selection of human iPSC-derived cardiomyocytes by sinGle cell geNe expression and pAtch clamp for a maTUre caRdiac modEl

Project Information

SiGNATURE

Grant agreement ID: 838985

DOI

10.3030/838985

Project closed

EC signature date 25 April 2019

Start date 1 February 2020

End date 31 January 2022

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 187 572,48

EU contribution

€ 187 572,48

Coordinated by

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (4)

Targeting the K v 11.1 (hERG) channel with allosteric modulators. Synthesis and biological evaluation of three novel series of LUF7346 derivatives

Author(s): J P D van Veldhoven, G Campostrini, C J E van Gessel, D Ward-van Oostwaard, R Liu, C L Mummery, M Bellin, A P IJzerman
Published in: European Journal of Medicinal Chemistry, Issue 212, 2021, Page(s) 113033., ISSN 0223-5234
Publisher: Elsevier BV
DOI: 10.1016/j.ejmech.2020.113033

Cardiac Tissues From Stem Cells: New Routes to Maturation and Cardiac Regeneration

Author(s): Giulia Campostrini, Laura M Windt, Berend J van Meer, Milena Bellin, Christine L Mummery
Published in: Circulation Research, Issue 128(6), 2021, Page(s) 775-801, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.121.318183

Generation, functional analysis and applications of isogenic three-dimensional self-aggregating cardiac microtissues from human pluripotent stem cells

Author(s): Giulia Campostrini, Viviana Meraviglia, Elisa Giacomelli, Ruben W J van Helden, Loukia Yiangou, Richard P Davis, Milena Bellin, Valeria V Orlova, Christine L Mummery
Published in: Nature Protocols, Issue 4, 2021, Page(s) 2213-2256, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-021-00497-2

Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease

Author(s): E Giacomelli, V Meraviglia, G Campostrini, A Cochrane, X Cao, R W J van Helden, A Krotenberg Garcia, M Mircea, S Kostidis, R P Davis, B J van Meer, C R Jost, A J Koster, H Mei, D G Míguez, A A Mulder, M Ledesma-Terrón, G Pompilio, L Sala, D C F Salvatori, R C Slieker, E Sommariva , A A F de Vries, M Giera, S Semrau, L G J Tertoolen, V V Orlova, M Bellin, C L Mummery
Published in: Cell Stem Cell, Issue 26(6), 2020, Page(s) 862-879, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2020.05.004