Targeting skin innervation for psoriasis treatment
Skin diseases are the most common human illnesses, with a third of the world population affected at any given time. The EU-funded NEUROSKIN project aims to determine how different skin innervations affect psoriasis, representing the largest class of skin conditions mediated by inflammation. The research will utilise a transgenic mouse model that enables optogenetic control of local peripheral innervations using light. The NEUROSKIN will take advantage of this tool to develop additional transgenic models relevant to cutaneous neuronal subpopulations. The models will allow control of the activity of neurons innervating the psoriatic plaques at different stages of the disease, providing potential new neuronal targets for interventions to treat inflammatory skin conditions.
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