Microscopy of living cancer cells at physiological oxygen levels: the MICROX platform

Project description

Microscopy at physiological oxygen levels

Drug research and development is replacing standard plate-reader assays with microscopy screening. Combined with innovative functional assays, it is possible to monitor dynamic events in living cells. The EU-funded MICROX will work on microscopy-assays that resemble the real oxygen levels that our cells encounter. Conventional protocols maintain cells at 21 % oxygen, whereas physiologically most cells are exposed to 2-5 % oxygen and cancer cells to hypoxic conditions. The resultant MICROX microscopy platform will offer the capacity to adjust atmospheric conditions according to cell type, and importantly, facilitate the discovery and screening of anticancer drugs.

Fields of science

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery
• engineering and technology › electrical engineering, electronic engineering, information engineering › electronic engineering › sensors › biosensors
• natural sciences › biological sciences › cell biology › cell signaling
• natural sciences › physical sciences › optics › microscopy
• medical and health sciences › clinical medicine › oncology

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2018 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2018

See other projects for this call

Funding Scheme

MSCA-IF-EF-CAR - CAR – Career Restart panel

Coordinator

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS

Net EU contribution

€ 281 358,72

Address

Plesmanlaan 121
1066 CX Amsterdam
Netherlands

Region

West-Nederland › Noord-Holland › Groot-Amsterdam

Activity type

Research Organisations

Links

Non-EU contribution

€ 0,00