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Microscopy of living cancer cells at physiological oxygen levels: the MICROX platform

Project description

Microscopy at physiological oxygen levels

Drug research and development is replacing standard plate-reader assays with microscopy screening. Combined with innovative functional assays, it is possible to monitor dynamic events in living cells. The EU-funded MICROX will work on microscopy-assays that resemble the real oxygen levels that our cells encounter. Conventional protocols maintain cells at 21 % oxygen, whereas physiologically most cells are exposed to 2-5 % oxygen and cancer cells to hypoxic conditions. The resultant MICROX microscopy platform will offer the capacity to adjust atmospheric conditions according to cell type, and importantly, facilitate the discovery and screening of anticancer drugs.

Coordinator

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Net EU contribution
€ 281 358,72
Address
Plesmanlaan 121
1066 CX Amsterdam
Netherlands

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Research Organisations
Non-EU contribution
€ 0,00