Project description
Microscopy at physiological oxygen levels
Drug research and development is replacing standard plate-reader assays with microscopy screening. Combined with innovative functional assays, it is possible to monitor dynamic events in living cells. The EU-funded MICROX will work on microscopy-assays that resemble the real oxygen levels that our cells encounter. Conventional protocols maintain cells at 21 % oxygen, whereas physiologically most cells are exposed to 2-5 % oxygen and cancer cells to hypoxic conditions. The resultant MICROX microscopy platform will offer the capacity to adjust atmospheric conditions according to cell type, and importantly, facilitate the discovery and screening of anticancer drugs.
Fields of science
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsbiosensors
- natural sciencesbiological sciencescell biologycell signaling
- natural sciencesphysical sciencesopticsmicroscopy
- medical and health sciencesclinical medicineoncology
Programme(s)
Funding Scheme
MSCA-IF-EF-CAR - CAR – Career Restart panel
Coordinator
1066 CX Amsterdam
Netherlands
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