Project description
Artificially mimicking the active sites of enzymes and surfaces
Funded under the Marie Skłodowska-Curie Actions programme, the MUSYCA project seeks to increase understanding of the key factors that govern carbon-hydrogen (C-H) bond activation mechanisms in dinuclear transition metal-based cores present in enzymes or surfaces. One of the main goals is to obtain complexes containing M2O entities that are reactive enough to oxidise C-H bonds. The project will use a wide variety of analytical techniques to study the reactivity patterns and the corresponding mechanisms underlying the formation of M-O fragments and those involving the C-O bond formation. The project will also develop unsymmetrical platforms for the development of heterobimetallic complexes to explore and understand the synergy between two transition metals in different chemical transformations.
Objective
MUSYCA - Multimetallic Systems for C-H Activation processes - is a project designed to obtain a better understanding of the key factors governing C-H activation phenomena in multinuclear copper-based cores present in the most efficient frameworks such as enzymes or zeolites like methane monooxygenases (MMOs) or Cu-ZSM-5, respectively. One of the main goals of the project is to obtain complexes containing Cu2O entities, which have not yet been interrogated and are reactive enough to oxidize C-H bonds. These will be employed in the stoichiometric and catalytic transformation of hydrocarbon bonds of numerous substrates, from easily convertible to extremely challenging ones, being methane the stretch goal. The reactivity patterns and the corresponding mechanisms underlying the formation of Cu-O fragments as well as those involving the formation of C-O bonds will be studied by using a wide variety of analytical techniques. To this end, robust 2,7-substituted [1,8]naphthyridine scaffolds will be employed as dinucleating ligands, since they resemble the environment surrounding dinuclear active sites in natural enzymes and they facilitate a close interaction between the metals, at the same time that the chelating groups in positions 2 and 7 help to stabilize the resulting complexes. These ligands will also be employed in the other major target of the project, which consists of the development of dinuclear Pt-Cu compounds so as to evaluate the metal cooperativity in a modified Shilov system for C-H activation. Only a few studies have been carried out on the role of copper in the Shilov-type C-H functionalization reaction, showing its great potential for improving the catalytic performance of the active species involved in the process. However, the role of Pt as active catalyst and Cu as oxidant in the same complex has never been investigated, and the aforementioned frameworks developed in the labs of Prof. Tilley are ideal for this purpose.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry inorganic compounds
- natural sciences chemical sciences organic chemistry hydrocarbons
- natural sciences chemical sciences catalysis
- natural sciences chemical sciences organic chemistry aliphatic compounds
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2018
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
41004 Sevilla
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.