Enhancing production and decreasing waste with pharma process modelling
Powders are the most common form for active pharmaceutical ingredients. They are more stable, and they are much easier and thus less expensive to store and transport than others. Granulation is the key process by which granules are produced from one or more powders to enable tableting for distribution. Twin screw granulation, accomplished with two extruder screws turning in opposite directions, is rapidly gaining interest as a promising method of continuous wet granulation, but deeper understanding of the granulation mechanisms and process parameters is required. The EU-funded MODSIM project is developing mathematical models of these particle processes in twin screw granulators on multiple scales to enhance the competitive position of EU pharma.