Periodic Reporting for period 1 - Nano_Brain (Improving drug delivery to the brain and glioblastoma treatment using temperature.)
Reporting period: 2019-07-01 to 2021-06-30
Currently, the aforementioned limitation limits the treatment of neurological diseases such as Glioblastoma, Parkinson and Stroke. With the lifespan expectancy currently increasing, finding those age-related diseases will be an important achievement for the society.
The overall objective are the detailed studies and understanding of both the intracellular temperature of the BBB endothelial cells temperature needed for the BBB opening and (2) design and synthesis of the nanocomplex capable of generate the temperature needed for the opening and for simultaneously release “in real-time and on-demand” of therapeutic drugs for glioblastoma treatment in vivo.
During these months, the nanoparticle necessary for the project has been designed and obtained. This nanoparticle has the capability of generating and measuring heat simultaneously. Thus, the nanoparticle is capable of opening the BBB and after future modification, it will be capable of release on demand anti-cancer drugs.
- In vitro intracellular temperature measurements for BBB opening
- Translation to in vivo model
- Design the GNR nano-complex for glioblastoma treatment