Uncover mechanisms of unconventional secretion of tau using functional CRISPR screens - From basic discoveries to neurodegenerative disease therapeutics

Project Information

SeCRT

Grant agreement ID: 842919

DOI 10.3030/842919

Project terminated on 28 November 2020

EC signature date 22 March 2019

Start date 1 April 2019

End date 31 March 2021

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 224 933,76

EU contribution € 224 933,76

Coordinated by

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Publications

Peer reviewed articles (3)

Mendelian neurodegenerative disease genes involved in autophagy

Author(s): Eleanna Stamatakou, Lidia Wróbel, Sandra Malmgren Hill, Claudia Puri, Sung Min Son, Motoki Fujimaki, Ye Zhu, Farah Siddiqi, Marian Fernandez-Estevez, Marco M. Manni, So Jung Park, Julien Villeneuve, David Chaim Rubinsztein
Published in: Cell Discovery, Issue 6/1, 2020, ISSN 2056-5968
Publisher: Springer Nature in partnership with the Center for Excellence in Molecular Cell Science
DOI: 10.1038/s41421-020-0158-y

New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells

Author(s): Laia Bassaganyas, Stephanie J. Popa, Max Horlbeck, Claudia Puri, Sarah E. Stewart, Felix Campelo, Anupama Ashok, Cristian M. Butnaru, Nathalie Brouwers, Kartoosh Heydari, Jean Ripoche, Jonathan Weissman, David C. Rubinsztein, Randy Schekman, Vivek Malhotra, Kevin Moreau, Julien Villeneuve
Published in: Journal of Cell Biology, Issue 218/11, 2019, Page(s) 3861-3879, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201902028

CD154 Induces Interleukin-6 Secretion by Kidney Tubular Epithelial Cells under Hypoxic Conditions: Inhibition by Chloroquine

Author(s): Antoine Dewitte, Julien Villeneuve, Sébastien Lepreux, Marion Bouchecareilh, Xavier Gauthereau, Claire Rigothier, Christian Combe, Alexandre Ouattara, Jean Ripoche
Published in: Mediators of Inflammation, Issue 2020, 2020, Page(s) 1-14, ISSN 0962-9351
Publisher: Hindawi Publishing Corporation
DOI: 10.1155/2020/6357046