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Uncover mechanisms of unconventional secretion of tau using functional CRISPR screens - From basic discoveries to neurodegenerative disease therapeutics

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Publications

New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells

Author(s): Laia Bassaganyas, Stephanie J. Popa, Max Horlbeck, Claudia Puri, Sarah E. Stewart, Felix Campelo, Anupama Ashok, Cristian M. Butnaru, Nathalie Brouwers, Kartoosh Heydari, Jean Ripoche, Jonathan Weissman, David C. Rubinsztein, Randy Schekman, Vivek Malhotra, Kevin Moreau, Julien Villeneuve
Published in: Journal of Cell Biology, Issue 218/11, 2019, Page(s) 3861-3879, ISSN 0021-9525
DOI: 10.1083/jcb.201902028

CD154 Induces Interleukin-6 Secretion by Kidney Tubular Epithelial Cells under Hypoxic Conditions: Inhibition by Chloroquine

Author(s): Antoine Dewitte, Julien Villeneuve, Sébastien Lepreux, Marion Bouchecareilh, Xavier Gauthereau, Claire Rigothier, Christian Combe, Alexandre Ouattara, Jean Ripoche
Published in: Mediators of Inflammation, Issue 2020, 2020, Page(s) 1-14, ISSN 0962-9351
DOI: 10.1155/2020/6357046