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Metal-dependent catalysis of nanozymes: First steps towards computational nanoenzymology

Project description

New models help scientists 'mining' for functionalised nanoparticle candidates

Gold nanoparticles have excellent biocompatibility and low toxicity and can be produced with a large spectrum of sizes and surface properties. Coating them with various surface monolayers imparts unique functionality for applications, from drug delivery and sensing to catalysis. The EU-funded CompNanozymes project will expand this repertoire with novel ‘nanozymes’ mimicking nature’s metalloenzymes that have a metal cation as a co-factor in the enzyme active site. These molecules process nucleic acids, and artificial ones could have an important impact on numerous medical and biotechnological applications. CompNanozymes will conduct an extensive modelling and experimental study of the mechanisms of nanozymes to advance our understanding of structure-function relationships to harness this amazing potential.

Coordinator

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Net EU contribution
€ 183 473,28
Address
Via Morego 30
16163 Genova
Italy

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Region
Nord-Ovest Liguria Genova
Activity type
Research Organisations
Other funding
€ 0,00