Interdisciplinary approach to characterize the structure and the ion transport mechanism of NKCC1, a key target for brain disorders.

Project Information

3D NKCC1

Grant agreement ID: 843239

DOI

10.3030/843239

Project closed

EC signature date 12 April 2019

Start date 1 July 2019

End date 30 June 2021

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 168 369,60

EU contribution

€ 168 369,60

Coordinated by

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (2)

Cation-coupled chloride cotransporters: chemical insights and disease implications

Author(s): Corinne Portioli, Manuel José Ruiz Munevar, Marco De Vivo, Laura Cancedda
Published in: Trends in Chemistry, 2021, ISSN 2589-5974
Publisher: Elsevier
DOI: 10.1016/j.trechm.2021.05.004

Design, Synthesis, In Vitro and In Vivo Characterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in Down Syndrome

Author(s): Marco Borgogno, Annalisa Savardi, Jacopo Manigrasso, Alessandra Turci, Corinne Portioli, Giuliana Ottonello, Sine Mandrup Bertozzi, Andrea Armirotti, Andrea Contestabile, Laura Cancedda, Marco De Vivo
Published in: Journal of Medicinal Chemistry, Issue 64/14, 2021, Page(s) 10203-10229, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00603