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Interdisciplinary approach to characterize the structure and the ion transport mechanism of NKCC1, a key target for brain disorders.

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Publications

Cation-coupled chloride cotransporters: chemical insights and disease implications

Author(s): Corinne Portioli, Manuel José Ruiz Munevar, Marco De Vivo, Laura Cancedda
Published in: Trends in Chemistry, 2021, ISSN 2589-5974
Publisher: Elsevier
DOI: 10.1016/j.trechm.2021.05.004

Design, Synthesis, In Vitro and In Vivo Characterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in Down Syndrome

Author(s): Marco Borgogno, Annalisa Savardi, Jacopo Manigrasso, Alessandra Turci, Corinne Portioli, Giuliana Ottonello, Sine Mandrup Bertozzi, Andrea Armirotti, Andrea Contestabile, Laura Cancedda, Marco De Vivo
Published in: Journal of Medicinal Chemistry, 64/14, 2021, Page(s) 10203-10229, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00603