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Study the functions of the hepatic sympathetic nerve and the receptor Adrb3 in liver-mediated adaptive thermogenesis.

Project description

Warming up to a new treatment target for liver disease

Thermogenesis literally means heat generation. Adaptive thermogenesis is another regulatory mechanism that occurs in response to changes in temperature and diet. It has gained increasing attention over the last decade for its potential role in obesity and prolonged dieting. It may also be important in liver disease, particularly non-alcoholic fatty liver disease (NAFLD) that is also associated with obesity and type 2 diabetes. The EU-funded Hepatic Thermogenesi project has targeted the liver as a potential site of adaptive thermogenesis. Scientists plan to tease out the molecular mechanisms and the role of sympathetic regulation. With NAFLD on the rise, results could provide new routes to treatment.

Coordinator

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Net EU contribution
€ 203 149,44
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Switzerland

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Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00