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The rise and fall of metastatic clones under immune attack

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Publications

dN/dS dynamics quantify tumour immunogenicity and predict response to immunotherapy

Author(s): Luis Zapata, Giulio Caravagna, Marc J Williams, Eszter Lakatos, Khalid AbdulJabbar, Benjamin Werner, Trevor A Graham, Andrea Sottoriva
Published in: BioRxiv, 2020, ISSN 0362-4331
DOI: 10.1101/2020.07.21.215038

Geospatial immune variability illuminates differential evolution of lung adenocarcinoma

Author(s): Khalid AbdulJabbar, Shan E. Ahmed Raza, Rachel Rosenthal, Mariam Jamal-Hanjani, Selvaraju Veeriah, Ayse Akarca, Tom Lund, David A. Moore, Roberto Salgado, Maise Al Bakir, Luis Zapata, Crispin T. Hiley, Leah Officer, Marco Sereno, Claire Rachel Smith, Sherene Loi, Allan Hackshaw, Teresa Marafioti, Sergio A. Quezada, Nicholas McGranahan, John Le Quesne, Charles Swanton, Yinyin Yuan
Published in: Nature Medicine, Issue 26/7, 2020, Page(s) 1054-1062, ISSN 1078-8956
DOI: 10.1038/s41591-020-0900-x

The rate and spectrum of mosaic mutations during embryogenesis revealed by RNA sequencing of 49 tissues

Author(s): Francesc Muyas, Luis Zapata, Roderic Guigó, Stephan Ossowski
Published in: Genome Medicine, Issue 12/1, 2020, ISSN 1756-994X
DOI: 10.1186/s13073-020-00746-1

Evolutionary dynamics of neoantigens in growing tumors

Author(s): Eszter Lakatos, Marc J. Williams, Ryan O. Schenck, William C. H. Cross, Jacob Househam, Luis Zapata, Benjamin Werner, Chandler Gatenbee, Mark Robertson-Tessi, Chris P. Barnes, Alexander R. A. Anderson, Andrea Sottoriva, Trevor A. Graham
Published in: Nature Genetics, Issue 52/10, 2020, Page(s) 1057-1066, ISSN 1061-4036
DOI: 10.1038/s41588-020-0687-1

Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking

Author(s): George D. Cresswell, Daniel Nichol, Inmaculada Spiteri, Haider Tari, Luis Zapata, Timon Heide, Carlo C. Maley, Luca Magnani, Gaia Schiavon, Alan Ashworth, Peter Barry, Andrea Sottoriva
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
DOI: 10.1038/s41467-020-15047-9

Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios

Author(s): Marc J Williams, Luis Zapata, Benjamin Werner, Chris P Barnes, Andrea Sottoriva, Trevor A Graham
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
DOI: 10.7554/elife.48714