Objective
The intramembrane proteolysis of the Amyloid Precursor Protein (APP) is the final step in the release of the amyloid peptide, the major constituent of the amyloid plaques in Alzheimer's disease. The protease complex responsible for this proteolytic event consists of Presenilin 1 or 2, Nicastrin, Aph1a or Aph1b, and Pen 2.
It is presently not known whether different gamma-secretase complexes exist or whether there is tissue and/or substrate specificity of these complexes. It is also unclear whether other proteins are involved in the regulation or activation of the complex. The current proposal aims to address the question on the function of Aph1a and b using cell biological and biochemical approaches in yeast, Mus Musculus and derived cell lines.
The results of this research will have implications for the better understanding of the novel cellular mechanism of regulated intramembrane proteolysis, and could also profoundly affect strategies to cure Alzheimer's disease aiming at lowering amyloid peptide production by targeting gamma-secretase processing of APP in a more specific way at the level of gamma-secretase.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences biological sciences biochemistry biomolecules proteins
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
ZWYNAARDE
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.