Gut-brain communication and obesity
Neural gut-brain communication helps to monitor gastrointestinal organs and contributes to energy and glucose homeostasis regulation. Its disruption develops in obesity and correlates with overeating and insulin resistance. This EU-funded project will employ a combination of modern molecular neuroscience tools and mouse genetic approaches to determine the identity of gut-innervating neurons, define their role in feeding behaviour and glucose metabolism, and map the neurocircuitry to downstream brain sites. Successful outcome of the project will help to overcome challenges associated with targeting distinct neurons in a cell-type and organ-specific manner, an important first step to developing new therapies to treat obesity.
Funding SchemeERC-STG - Starting Grant