Dynamic Growth and Replication in Coacervate Protocells

Project Information

DynaGrow

Grant agreement ID: 851963

DOI

10.3030/851963

Project closed

EC signature date 8 October 2019

Start date 1 March 2020

End date 28 February 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

STICHTING RADBOUD UNIVERSITEIT
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

Participation in the Open Research Data Pilot

Publications

Peer reviewed articles (16)

Quantification of Biomolecular Condensate Volume Reveals Network Swelling and Dissolution Regimes during Phase Transition

Author(s): Iris B. A. Smokers, Evan Spruijt
Published in: Biomacromolecules, 2024, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.4c01201

Probing the surface charge of condensates using microelectrophoresis

Author(s): Merlijn van Haren, Brent Visser, Evan Spruijt
Published in: Nature Communications, Issue 15, 2023, Page(s) 3564, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.26434/chemrxiv-2023-tgtd7

How Droplets Can Accelerate Reactions─Coacervate Protocells as Catalytic Microcompartments

Author(s): Iris B. A. Smokers, Brent S. Visser, Annemiek D. Slootbeek, Wilhelm T. S. Huck, Evan Spruijt
Published in: Accounts of Chemical Research, Issue 57, 2024, Page(s) 1885-1895, ISSN 0001-4842
Publisher: American Chemical Society
DOI: 10.1021/acs.accounts.4c00114

A short peptide synthon for liquid-liquid phase separation

Author(s): Manzar Abbas, Wojciech P. Lipiński, Karina K. Nakashima, Wilhelm T. S. Huck and Evan Spruijt
Published in: Nature Chemistry, Issue 17554330, 2021, Page(s) 1046-1054, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-021-00788-x

Fibrils Emerging from Droplets: Molecular Guiding Principles behind Phase Transitions of a Short Peptide-Based Condensate Studied by Solid-State NMR

Author(s): Wojciech P. Lipiński, Johannes Zehnder, Manzar Abbas, Peter Güntert, Evan Spruijt, Thomas Wiegand
Published in: Chemistry A European Journal, Issue 29, 2023, Page(s) e202301159, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202301159

Peptide‐Based Coacervate‐Core Vesicles with Semipermeable Membranes

Author(s): Manzar Abbas; Jack O. Law; Sushma N. Grellscheid; Wilhelm T. S. Huck; Evan Spruijt
Published in: Advanced Materials, Issue 15214095, 2022, Page(s) 2202913, ISSN 1521-4095
Publisher: Wiley Inc
DOI: 10.1002/adma.202202913

Shape transformations in peptide–DNA coacervates driven by enzyme-catalyzed deacetylation

Author(s): Merlijn H. I. van Haren, Nienke S. Helmers, Luuk Verploegen, Viveca A. C. Beckers, Evan Spruijt
Published in: Soft Matter, Issue 20, 2024, Page(s) 9493-9502, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4sm01091d

Phase‐separated Droplets Can Direct the Kinetics of Chemical Reactions Including Polymerization, Self‐replication and Oscillating Networks

Author(s): Iris B. A. Smokers, Brent S. Visser, Wojciech P. Lipiński, Karina K. Nakashima, Evan Spruijt
Published in: ChemSystemsChem, 2024, Page(s) e202400056, ISSN 2570-4206
Publisher: Wiley-VCH
DOI: 10.1002/syst.202400056

Selective amide bond formation in redox-active coacervate protocells

Author(s): Jiahua Wang, Manzar Abbas, Junyou Wang, Evan Spruijt
Published in: Nature Communications, Issue 14, 2023, Page(s) 8492, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-44284-x

Complex coacervation and compartmentalized conversion of prebiotically relevant metabolites

Author(s): Iris B. A. Smokers, Merlijn H. I. van Haren, Tiemei Lu and Evan Spruijt
Published in: ChemSystemsChem, Issue 25704206, 2022, Page(s) e202200004, ISSN 2570-4206
Publisher: Wiley-VCH
DOI: 10.1002/syst.202200004

Growth, replication and division enable evolution of coacervate protocells

Author(s): Annemiek D. Slootbeek, Merlijn H. I. van Haren, Iris B. A. Smokers and Evan Spruijt
Published in: Chemical Communications, Issue 1364548X, 2022, Page(s) 11183-11200, ISSN 1364-548X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2cc03541c

Open questions on liquid–liquid phase separation

Author(s): Evan Spruijt
Published in: Communcations Chemistry, Issue 1, 2023, Page(s) 23, ISSN 2399-3669
Publisher: Springer Nature
DOI: 10.1038/s42004-023-00823-7

Aqueous coordination polymer complexes: From colloidal assemblies to bulk materials

Author(s): Jiahua Wang, Tiemei Lu,Yuehua Li, Junyou Wang, Evan Spruijt
Published in: Advances in Colloid and Interface Science, Issue 318, 2023, Page(s) 102964, ISSN 0001-8686
Publisher: Elsevier BV
DOI: 10.1016/j.cis.2023.102964

Controlling Multiphase Coacervate Wetting and Self-Organization by Interfacial Proteins

Author(s): Tiemei Lu, Susanne Liese, Brent S. Visser, Merlijn H. I. van Haren, Wojciech P. Lipiński, Wilhelm T. S. Huck, Christoph A. Weber, Evan Spruijt
Published in: Journal of the American Chemical Society, Issue 147, 2025, Page(s) 22622-22633, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.5c03870

Selective Ion Binding and Uptake Shape the Microenvironment of Biomolecular Condensates

Author(s): Iris B. A. Smokers, Enrico Lavagna, Rafael V. M. Freire, Matteo Paloni, Ilja K. Voets, Alessandro Barducci, Paul B. White, Mazdak Khajehpour, Evan Spruijt
Published in: Journal of the American Chemical Society, Issue 147, 2025, Page(s) 25692-25704, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.5c07295

Peptide-based coacervates as biomimetic protocells

Author(s): Manzar Abbas; Wojciech P. Lipiński; Jiahua Wang; Evan Spruijt
Published in: Chemical Society Reviews, Issue 1, 2021, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cs00307g

Non-peer reviewed articles (1)

Peptide-based liquid droplets as emerging delivery vehicles

Author(s): Jianhui Liu, Evan Spruijt, Ali Miserez, Robert Langer
Published in: Nature Reviews Materials, Issue 8, 2023, Page(s) 139-141, ISSN 2058-8437
Publisher: Nature Publishing Group
DOI: 10.1038/s41578-022-00528-8

Thesis and dissertations (1)

Measuring and manipulating charge in coacervates

Author(s): Merlijn H. I. van Haren
Published in: 2025
Publisher: Radboud University