Project description
Neuronal courier services may do more than just deliver the goods
The messenger RNA, or mRNA, carries the genetic message from the nucleus into the cytoplasm where it is translated into a protein by ribosomes. How cells regulate where and when protein synthesis occur in very complex cells such as neurons remain a very active area of research. The EU-funded AXONENDO project is building on the discovery that mRNAs and ribosomes are present on moving vesicles called endosomes in the axons of neurons, hoping to tease out the mechanisms and a potential role in development and neuronal function. Endosomal trafficking in axons and dendrites is like a neuronal courier for fast and effective point-to-point delivery of goods. Now it could also play a key role in changing local protein expression in response to extracellular factors.
Fields of science
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Funding Scheme
ERC-STG - Starting Grant
Host institution
20132 Milano
Italy
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Beneficiaries (1)
20132 Milano
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