Transcription-replication conflicts in disease and development

Project Information

ConflictResolution

Grant agreement ID: 852798

DOI

10.3030/852798

Project closed

EC signature date 25 October 2019

Start date 1 February 2020

End date 30 November 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 497 530,00

EU contribution

€ 1 497 530,00

Coordinated by

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Non-peer reviewed articles (1)

A quick restart: RNA polymerase jumping onto post-replicative chromatin

Author(s): Marcel Werner, Stephan Hamperl
Published in: Molecular Cell, Issue 84, 2025, Page(s) 186-188, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2023.12.029

Peer reviewed articles (6)

Single-copy locus proteomics of early- and late-firing DNA replication origins identifies a role of Ask1/DASH complex in replication timing control

Author(s): Matthias Weiβ, Anna Chanou, Tamas Schauer, Andrey Tvardovskiy, Stefan Meiser, Ann-Christine König, Tobias Schmidt, Elisabeth Kruse, Henning Ummethum, Manuel Trauner, Marcel Werner, Maxime Lalonde, Stefanie M. Hauck, Antonio Scialdone, Stephan Hamperl
Published in: Cell Reports, Issue 42, 2025, Page(s) 112045, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.112045

Proximity Labeling Techniques to Study Chromatin

Author(s): Henning Ummethum, Stephan Hamperl
Published in: Frontiers in Genetics, Issue 11, 2020, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2020.00450

Consequences and Resolution of Transcription–Replication Conflicts

Author(s): Maxime Lalonde, Manuel Trauner, Marcel Werner, Stephan Hamperl
Published in: Life, Issue 11/7, 2021, Page(s) 637, ISSN 2075-1729
Publisher: MDPI
DOI: 10.3390/life11070637

Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability

Author(s): Carlos Origel Marmolejo, Celina Sanchez, Erin Helms, Melissa J. McEvoy, Juyoung Lee, Marcel Werner, Paige Roberts, Stephan Hamperl, Joshua C. Saldivar
Published in: Molecular Cell, Issue 86, 2026, Page(s) 640-655.e6, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2026.01.005

The CGG triplet repeat binding protein 1 counteracts R-loop induced transcription-replication stress

Author(s): Henning Ummethum, Augusto C Murriello, Marcel Werner, Elizabeth Márquez-Gómez, Ann-Christine König, Elisabeth Kruse, Maxime Lalonde, Manuel Trauner, Anna Chanou, Matthias Weiβ, Clare S K Lee, Andreas Ettinger, Florian Erhard, Stefanie M Hauck, Stephan Hamperl
Published in: EMBO Reports, Issue 26, 2025, Page(s) 4691-4722, ISSN 1469-3178
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44319-025-00550-1

Transcription-replication conflicts drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery

Author(s): Marcel Werner, Manuel Trauner, Tamas Schauer, Henning Ummethum, Elizabeth Márquez-Gómez, Maxime Lalonde, Clare S K Lee, Ioannis Tsirkas, Atiqa Sajid, Augusto C Murriello, Gernot Längst, Stephan Hamperl
Published in: Nucleic Acids Research, Issue 53, 2025, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaf109