Bioenergetics of synaptic transmission
Synaptic transmission is an energy-dependent process that consumes up to 75 % of the total energy required for brain function. The metabolic pathways of ATP production have been studied in detail, but actual molecular regulation of synaptic bioenergetics, and how synapses obtain the required amount of ATP, is poorly understood. The EU-funded SynaptoEnergy project aims to investigate molecular mechanisms controlling energy pathways in firing synapses. The working hypothesis of the project is that there are presynaptic tightly regulated control mechanisms enabling molecular activation of the glycolysis and the oxidative phosphorylation on demand coupling local ATP synthesis to required level of consumption. The research will utilise cutting-edge optophysiology tools to study neuronal bioenergetics together with novel proteomics approaches to identify key molecular players involved in controlling presynaptic energy production.
Call for proposalSee other projects for this call
Funding SchemeERC-STG - Starting Grant
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