It is becoming increasingly clear that successful tissue engineering rests on capitalizing on more comprehensive understanding of mechanotransduction. In fact, the study of mechanotransduction is now a burgeoning research field, helping us to understand how cells respond to mechanical stimuli and convert them into biochemical signals, which in turn sheds light on the remote control of intracellular functions and the treatment of diseases. However, external manipulation of cellular signalling constitutes an important challenge due to the lack of non-invasive techniques that can be tuned in a spatiotemporal manner at a deep-tissue level. SIROCCO aims to control different pathways related with cutaneous mechanotransduction by using magnetic nanoparticles in order to enhance wound healing. External magnetic fields will be applied to magnetic nanoparticles selectively attached to the membrane of living cells in order to create a force that can activate key intracellular pathways connected with mechanotransduction. Using genetically modified 2D and 3D in vitro models, the possibility to activate important pathways in order to enhance wound healing will be tested.