Project description
Biomarkers to diagnose skin lesions that predict arthritis
The body's ability to fight disease relies on its immune system, and that includes the skin and mucous membranes which act as a protective barrier against the outside world. Increasing evidence points to the important interrelationship between immunity and inflammation. Psoriatic arthritis is just one such example: it is one of the most common types of autoimmune arthritis and a prototype inflammatory disease. Despite beginning as psoriasis (also an immune-mediated disease), this initial phase does not always lead to inflammation of joints and tendons - and the reasons are not known. The EU-funded BARRIER BREAK project is studying the spread of the disease to musculoskeletal regions in a novel model of psoriatic arthritis, on the trail of biomarkers for early diagnosis and treatment.
Objective
Physical barriers of the body and their immunological dysregulation are connected to a variety of inflammatory diseases and therefore an emerging area of interest in medicine. The gut and its microbiome gained center stage, whereas the skin as large primary immunological barrier to the environment is still less appreciated. Psoriatic arthritis (PsA) is a prototypic inflammatory disease which usually starts with skin lesions, before spreading to the musculoskeletal regions. To date, it is still obscure why the inflammatory process in some patients with psoriasis is restrained to the skin, whereas in other patients it extends to tendons and joints. Moreover, disease spreading to the joints associates with local tissue remodelling as evidenced by new bone formation at the insertion site of tendons into the bones. The molecular and cellular regulation of this “skin-joint axis” leading to development of PsA is still unclear but essential to understand organ communication in inflammatory diseases, the identification of potential biomarkers for early recognition of the disease and the development of preventive treatments. We will take advantage of a new model resembling PsA, which was established in our lab, with the aim of (1) studying disease spreading from the skin to musculoskeletal regions, (2) deciphering the molecular mechanisms that lead to uncontrolled local tissue remodeling, and finally (3) testing a new translational approach to prevent spreading of inflammation and tissue remodelling. We plan to adopt cutting-edge techniques to achieve our goals, which in turn will contribute to a better knowledge of the connection between epithelial surfaces and inflammation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine rheumatology
- natural sciences biological sciences microbiology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-STG - Starting Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2019-STG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
91054 ERLANGEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.