CORDIS provides links to public deliverables and publications of HORIZON projects.
Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .
Deliverables
Update of the report will describe the results obtained by the various efforts to identify and/or validate predictive TB biomarkers.
First study subject approvals package for molecule TBAJ587 (opens in new window)Includes final version of study protocol as approved by first regulatorethics committees registration number of clinical study in a WHO or ICMJE approved registry and the approvals required for the enrolment of first subject in at least one clinical centre according to EU and national legislation Study protocol will be developed by SERMAS in collaboration with CTUs and EFPIA partners according to ICHE6R2 Guideline For Good Clinical Practice Scheduled CDGO plus 11 months
First report on molecular signatures of anti-TB drug treatment efficacy in the three animal models (opens in new window)This report will describe molecular signature data obtained during antiTB treatment in selected mouse and NHP models Updates M48 M72
Initial report on recommendations for design, dosing and sampling schedule for selected experimental protocols in WPs 2, 3 and 4. (opens in new window)An overview of potential limitations will be presented along with the agreed recommendations for optimisation of experimental protocols Update M36
Second Report on clinical and preclinical datasets standardized and integrated into the DDIM (opens in new window)Second report on the quantity and status of datasets integrated into the DSP This report will also serve to provide best practices and lessons learned to drive continuous improvement in the data collaboration processes
Third Report on clinical and preclinical datasets standardized and integrated into the DDIM (opens in new window)Third report on the quantity and status of datasets integrated into the DSP. This report will also serve to provide best practices and lessons learned to drive continuous improvement in the data collaboration processes.
First Report on implementation of selected mouse models for in vivo evaluation of drug candidates (opens in new window)This report will describe the different mouse models that were established optimized in the partners institutions for the in vivo evaluation of new antiTB compounds Updates M24 M48
Second report on implementation of selected mouse models for in vivo evaluation of drug candidates (opens in new window)This report will describe the different mouse models that were established optimized in the partners institutions for the in vivo evaluation of new antiTB compounds
Project communication plan and initial toolset (opens in new window)A plan for dissemination that includes the communication objectives, target audiences, activities to be carried out and tools that will support their implementation, with connections among these components. It will also include an initial set of communication materials.
Initial standardized templates for collection and reporting of clinical and preclinical data available to consortium members (opens in new window)Initial data collection templates for use by Consortium members for the collection and integration of data. Templates will be generated as soon as possible based on input from Consortium members, and early reviews of the data generated within the Consortium. Data collection templates will evolve throughout the project based on knowledge and experience gained. (Updated M16)
First study subject approvals package (opens in new window)Includes final version of study protocol as approved by first regulator/ethics committee(s), registration number of clinical study in a WHO- or ICMJE- approved registry and the approvals required for the enrolment of first subject in at least one clinical centre according to EU and national legislation. Study protocol will be developed by SERMAS in collaboration with CTUs and EFPIA partners according to ICH-E6(R2) “Guideline For Good Clinical Practice”. Due date will relate to the Commit Decision to GO (CDGO) for each FTIH trial plus 4 months.
Standardized templates for collection and reporting of clinical and preclinical data available to consortium members -interim report (opens in new window)Data collection templates for use by Consortium members for the collection and integration of data
Third report on implementation of selected mouse models for in vivo evaluation of drug candidates (opens in new window)This report will describe the different mouse models that were established / optimized in the partner’s institutions for the in vivo evaluation of new anti-TB compounds.
First Report on clinical and preclinical datasets standardized and integrated into the DDIM (opens in new window)First of a series of periodic report on the quantity and status of datasets integrated into the DSP This report will also serve to provide best practices and lessons learned to drive continuous improvement in the data collaboration processes
First Report on discovery and validation of predictive TB biomarkers (opens in new window)This report will describe the results obtained by the various efforts to identify andor validate predictive TB biomarkers Updates M48 M72
Final report on recommendations for design, dosing and sampling schedule for selected experimental protocols in WPs 2, 3 and 4. (opens in new window)An overview of potential limitations will be presented along with the agreed recommendations for optimisation of experimental protocols.
Report on instantiation of EU-based Drug Development Information Management (DDIM) system (opens in new window)An initial report to provide early status on the deployment of the DDIM and the underlying clinical and preclinical data management systems, image store and common user interface.
Initial molecular imaging systems, procedures and protocols to perform quantitative, dynamic PET/CT and NIR imaging studies in BSL3 conditions in mouse models (opens in new window)Initial report on the molecular imaging systems procedures and protocols to perform quantitative dynamic PETCT and NIR imaging studies in BSL3 conditions in mouse models Updated M70
Project Handbook (opens in new window)Quick reference manual for partners to consult management procedures, including relevant provisions of the GA/CA in an easy to understand language. It will also explain the tools set up to facilitate collaborative work across the Consortium.
Development and optimization of NHP models for TB drug efficacy evaluation (opens in new window)Report on the efforts made to develop and optimize the marmoset and macaque models for evaluating treatment efficacy of new anti-TB compounds under conditions that closer resemble the situation in humans than murine models.
HFS-TB implementation at UNIZAR to meets industry-level standards for data quality, experimental design and integrity, throughput, analysis, and reporting.
Platform for supervised and automatic image analysis (opens in new window)Imaging platform to define and quantify translational biomarkers from in vivo PET/CT molecular imaging across species (mouse, NHP and human)
Initial molecular imaging systems, procedures and protocols to perform quantitative, dynamic PET/CT studies in BSL3 conditions in NHP models (opens in new window)Initial molecular imaging systems procedures and protocols to perform quantitative dynamic PETCT studies in BSL3 conditions in NHP models Updated M70
Efficient pipeline and logistic resources to image infected tissue (opens in new window)Demonstration of the use of MALDI-MS imaging technologies and means for sharing the samples with no BSL3 SI services constrains to image infected tissues within the pipeline context.
Negotiations with the owners of legacy clinical and preclinical datasets generated prior to the existence of the ERA4TB Consortium or in parallel will be conducted and if permitted will be made available to consortium members This may occur prior to the full implementation of the DDIM so alternative means for dissemination of this data may be used eg via existing data platforms or temporary databases
Publications
Author(s):
Marina Cañadas-Ortega, Clara Gómez-Cruz, Juan José Vaquero, Arrate Muñoz-Barrutia
Published in:
Nanotechnology Reviews, Issue 11, 2022, Page(s) 40-54, ISSN 2191-9097
Publisher:
Walter de Gruyter GmbH
DOI:
10.1515/ntrev-2022-0004
Author(s):
Lara Visuña, Dandi Yang, Javier Garcia-Blas and Jesus Carretero
Published in:
BMC medical imaging, 2022, Page(s) 22, 178., ISSN 1471-2342
Publisher:
BioMed Central
DOI:
10.1186/s12880-022-00904-4
Author(s):
Chiara Toniolo, Neeraj Dhar, John D McKinney
Published in:
EMBO Journal, 2023, ISSN 0261-4189
Publisher:
Nature Publishing Group
DOI:
10.1101/2023.01.11.523669
Author(s):
Roxane Simeone, Fadel Sayes, Emeline Lawarée, Roland Brosch
Published in:
Cellular Microbiology, Issue 23, 2023, ISSN 1462-5814
Publisher:
Blackwell Publishing Inc.
DOI:
10.1111/cmi.13344
Author(s):
S. Basak, D. Deb, U. Narsaria, T. Kar, F. Castiglione, I. Sanyal, P. D. Bade, A. P. Srivastava
Published in:
Scientific Reports, Issue 11, 2021, Page(s) 14215, ISSN 2045-2322
Publisher:
Nature Publishing Group
DOI:
10.1038/s41598-021-93305-6
Author(s):
Griego A, Douché T, Gianetto QG, Matondo M, Manina G.
Published in:
iScience, 2022, Page(s) Vol. 25Issue 5, ISSN 1097-4172
Publisher:
Cell Press
DOI:
10.1016/j.isci.2022.104233
Author(s):
Raphael Gries, Jason Chhen, Edeltraud van Gumpel, Sebastian J. Theobald, Lindsay Sonnenkalb, Christian Utpatel, Fabian Metzen, Manuel Koch, Tobias Dallenga, Kamel Djaout, Alain Baulard, Michael Dal Molin, Jan Rybniker
Published in:
Cell Chemical Biology, Issue 31, 2024, Page(s) 699-711.e6, ISSN 2451-9456
Publisher:
Cell Press
DOI:
10.1016/j.chembiol.2023.12.007
Author(s):
Dandi Yang, Cristhian Martinez, Lara Visuña, Hardev Khandhar, Chintan Bhatt, Jesus Carretero
Published in:
Scientific Reports, Issue 11/1, 2021, ISSN 2045-2322
Publisher:
Nature Publishing Group
DOI:
10.1038/s41598-021-99015-3
Author(s):
Sarosh Nagar, David Nicholls, Dalia Dawoud
Published in:
Frontiers in Public Health, Issue 12, 2024, ISSN 2296-2565
Publisher:
Frontiers Media SA
DOI:
10.3389/fpubh.2024.1201512
Author(s):
Rob C van Wijk, Ainhoa Lucía, Pavan Kumar Sudhakar, Lindsay Sonnenkalb, Cyril Gaudin, Eik Hoffmann, Bérénice Dremierre, Diana Angélica Aguilar-Ayala, Michael Dal Molin, Jan Rybniker, Stefano de Giorgi, Laura Cioetto-Mazzabò, Greta Segafreddo, Riccardo Manganelli, Giulia Degiacomi, Deborah Recchia, Maria Rosalia Pasca, Ulrika S H Simonsson, Santiago Ramón-García
Published in:
Nature Communications, Issue 11, 2023, Page(s) Volume 26, Issue 4, 21 April 2023, 106411, ISSN 2041-1723
Publisher:
Nature Publishing Group
DOI:
10.1016/j.isci.2023.106411
Author(s):
Francesca Boldrin, Roberta Provvedi, Laura Cioetto Mazzabò, Greta Segafreddo, Riccardo Manganelli
Published in:
Frontiers in Microbiology, Issue 11, 2020, ISSN 1664-302X
Publisher:
Frontiers Media
DOI:
10.3389/fmicb.2020.01924
Author(s):
Tamalika Kar, Utkarsh Narsaria, Srijita Basak, Debashrito Deb, Filippo Castiglione, David M. Mueller, Anurag P. Srivastava
Published in:
Scientific Reports, Issue 10/1, 2020, Page(s) 10895, ISSN 2045-2322
Publisher:
Nature Publishing Group
DOI:
10.1038/s41598-020-67749-1
Author(s):
Mickael Orgeur, Camille Sous, Jan Madacki, Roland Brosch
Published in:
FEMS Microbiology Reviews, Issue 48, 2024, ISSN 1574-6976
Publisher:
Oxford University Press
DOI:
10.1093/femsre/fuae006
Author(s):
F. Castiglione, D. Deb, A.P. Srivastava, P. Lio`, A. Liso
Published in:
Frontiers in Immunology, Issue 12, 2021, Page(s) 3433-3449, ISSN 1664-3224
Publisher:
Frontiers
DOI:
10.3389/fimmu.2021.646972
Author(s):
Richa Mishra, Melanie Hannebelle, Vishal P. Patil, Anaëlle Dubois, Cristina Garcia-Mouton, Gabriela M. Kirsch, Maxime Jan, Kunal Sharma, Nicolas Guex, Jessica Sordet-Dessimoz, Jesus Perez-Gil, Manu Prakash, Graham W. Knott, Neeraj Dhar, John D. McKinney, Vivek V. Thacker
Published in:
Cell, Issue 186, 2023, Page(s) 5135-5150.e28, ISSN 0092-8674
Publisher:
Cell Press
DOI:
10.1016/j.cell.2023.09.016
Author(s):
Alan Faraj, Oskar Clewe, Robin J. Svensson, Galina V. Mukamolova, Michael R. Barer, Ulrika S. H. Simonsson
Published in:
Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher:
Nature Publishing Group
DOI:
10.1038/s41598-020-72472-y
Author(s):
Paloma Moraga, Paula Prieto, Almari Conradie, Majda Benhayoun, Vicki Rousell, Maria Davy, Uwe Fuhr, Rosa Antonijoan Arbos, Francisco Abad‐Santos, Antonio Portolés, Jolanda Van Duinen, Antonio J. Carcas, Alberto M. Borobia, null null
Published in:
Clinical and Translational Science, Issue 16, 2024, Page(s) 2421-2428, ISSN 1752-8054
Publisher:
Wiley-Blackwell
DOI:
10.1111/cts.13655
Author(s):
Mistretta M, Gangneux N, Manina G.
Published in:
Scientific Reports, 2022, Page(s) 19578 (2022), ISSN 2045-2322
Publisher:
Nature Publishing Group
DOI:
10.1038/s41598-022-24175-9
Author(s):
Raphael Gries, Michael Dal Molin, Jason Chhen, Edeltraud van Gumpel, Viola Dreyer, Stefan Niemann, Jan Rybniker
Published in:
Antimicrobial Agents and Chemotherapy, Issue 67, 2023, ISSN 0066-4804
Publisher:
American Society for Microbiology
DOI:
10.1128/aac.00251-23
Author(s):
Julia D. Knopf, Susanne S. Steigleder, Friederike Korn, Nathalie Kühnle, Marina Badenes, Marina Tauber, Sebastian J. Theobald, Jan Rybniker, Colin Adrain, Marius K. Lemberg
Published in:
Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher:
Nature Publishing Group
DOI:
10.1038/s41467-024-45615-2
Author(s):
Camille Sous, Wafa Frigui, Alexandre Pawlik, Fadel Sayes, Laurence Ma, Thomas Cokelaer, Roland Brosch
Published in:
Microbiology Spectrum, Issue 12, 2024, ISSN 2165-0497
Publisher:
ASM Press
DOI:
10.1128/spectrum.04126-23
Author(s):
Isabelle Suárez, Dominic Rauschning, Cora Schüller, Anna Hagemeier, Melanie Stecher, Clara Lehmann, Philipp Schommers, Stefan Schlabe, Jörg-Janne Vehreschild, Carolin Koll, Carolynne Schwarze-Zander, Jan-Christian Wasmuth, Angela Klingmüller, Jürgen Kurt Rockstroh, Gerd Fätkenheuer, Christoph Boesecke, Jan Rybniker
Published in:
Infection, Issue 52, 2024, Page(s) 1439-1448, ISSN 0300-8126
Publisher:
Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI:
10.1007/s15010-024-02215-y
Author(s):
Diana A. Aguilar‐Ayala, Fernando Sanz‐García, Marie Sylvianne Rabodoarivelo, Budi O. Susanto, Rebeca Bailo, Maxime R. Eveque‐Mourroux, Nicolas Willand, Ulrika S. H. Simonsson, Santiago Ramón‐García, Ainhoa Lucía, null null
Published in:
British Journal of Clinical Pharmacology, Issue 90, 2024, Page(s) 1711-1727, ISSN 0306-5251
Publisher:
Blackwell Publishing Inc.
DOI:
10.1111/bcp.16068
Author(s):
Amaro Torres-Simón, María Henar Marino, Clara Gómez-Cruz, Marina Cañadas, Miguel Marco, Jorge Ripoll, Juan José Vaquero, Arrate Muñoz-Barrutia
Published in:
Sensors, Issue 20/15, 2020, Page(s) 4140, ISSN 1424-8220
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/s20154140
Author(s):
Marina Cañadas-Ortega, Clara Gómez-Cruz, Juan José Vaquero & Arrate Muñoz-Barrutia
Published in:
Springer nature, Issue Integrated Science ((IS,volume 11)), 2023
Publisher:
Springer nature
Author(s):
Lara Visuña, Javier Garcia-Blas, Jesus Carretero
Published in:
Lecture Notes in Networks and Systems, Proceedings of the Second International Conference on Advances in Computing Research (ACR’24), 2024, Page(s) 195-205
Publisher:
Springer Nature Switzerland
DOI:
10.1007/978-3-031-56950-0_17
Author(s):
Pedro M. Gordaliza, Juan José Vaquero, Arrate Muñoz-Barrutia
Published in:
arXiv, 2022, ISSN 2331-8422
Publisher:
ArXiV
DOI:
10.48550/arxiv.2203.01668
Author(s):
Josepine Fernow, Marie Olliver, William Couet, Sophie Lagrange, Meindert H. Lamers, Ole F. Olesen, Kristina Orrling, Michel Pieren, Derek J. Sloan, Juan José Vaquero, Timothy J. Miles, Anders Karlén
Published in:
Nature Reviews Drug Discovery, Issue 24, 2025, Page(s) 1-2, ISSN 1474-1776
Publisher:
Nature Publishing Group
DOI:
10.1038/d41573-024-00138-9
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