Better control and treatment of immune-mediated diseases by exploring the universe of microenvironment imposed tissue signatures and their correlates in liquid biopsies

Project Information

ImmUniverse

Grant agreement ID: 853995

DOI

10.3030/853995

Project closed

EC signature date 17 December 2019

Start date 1 January 2020

End date 30 June 2026

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 31 110 000,00

EU contribution

€ 15 500 000,00

Coordinated by

UNIVERSITA HUMANITAS
Italy

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

External project website

Publications

Peer reviewed articles (13)

Large-scale analysis of temporal gene expression variation in peripheral blood

Author(s): Neha Mishra, Franziska Kimmig, Doris Vandeputte, Valentina Talevi, Lindsey De Commer, Chloe Verspecht, Arnau Vich Vila, Julia S. El-Sayed Moustafa, Lukasz Kreft, Alexander Botzki, Youssef El Darzi, Sebastian Proost, Lindsay Devolder, Dongmeng Wang, Joana P. Bernardes, N. Ahmad Aziz, null null, Konrad Aden, Vibeke Andersen, Aggelos Banos, George Bertsias, Marc Beyer, Johanna I. Blase, Dimitrios Bou
Published in: Nature Communications, Issue 17, 2026, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-026-73218-6

Patient Reported Outcomes in Chronic Inflammatory Diseases: Current State, Limitations and Perspectives

Author(s): Florian Tran, Jan Henrik Schirmer, Ilka Ratjen, Wolfgang Lieb, Philip Helliwell, Johan Burisch, Juliane Schulz, Florian Schrinner, Charlot Jaeckel, Ulf Müller-Ladner, Stefan Schreiber and Bimba F. Hoyer
Published in: Frontiers in Immunology, 2021, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.614653

The Inflammatory Bowel Disease Transcriptome and Metatranscriptome Meta-Analysis (IBD TaMMA) framework.

Author(s): Luca Massimino, Luigi Antonio Lamparelli, Yashar Houshyar, Silvia D’Alessio, Laurent Peyrin-Biroulet, Stefania Vetrano, Silvio Danese, and Federica Ungaro
Published in: Nature Computational Science, 2021, ISSN 2662-8457
Publisher: Springer Nature
DOI: 10.1038/s43588-021-00114-y

Tryptophan degradation as a systems phenomenon in inflammation – an analysis across 13 chronic inflammatory diseases

Author(s): Danielle M.M. Harris, Silke Szymczak, Sven Schuchardt, Johannes Labrenz, Florian Tran, Lina Welz, Hanna Graßhoff, Henner Zirpel, Melike Sümbül, Mhmd Oumari, Nils Engelbogen, Ralf Junker, Claudio Conrad, Diamant Thaçi, Norbert Frey, Andre Franke, Stephan Weidinger, Bimba Hoyer, Philip Rosenstiel, Silvio Waschina, Stefan Schreiber, Konrad Aden
Published in: eBioMedicine, Issue 102, 2025, Page(s) 105056, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2024.105056

DOP090 Serum metabolites predict endoscopic disease activity and clinical and endoscopic remission in Ulcerative Colitis

Author(s): L Welz, D Harris, S Schuchardt, F Tran, S Waschina, B Verstockt, S Vermeire, P Rosenstiel, S Schreiber, K Aden
Published in: Journal of Crohn's and Colitis, Issue 19, 2025, Page(s) i248-i250, ISSN 1873-9946
Publisher: Elsevier Science
DOI: 10.1093/ecco-jcc/jjae190.0129

Evaluation of Commercially Available Kits for Parallel DNA and microRNA Isolation Suitable for Epigenetic Analyses from Cell-Free Saliva and Salivary Extracellular Vesicles

Author(s): Iqra Yousaf, Ulrike Kegler, Manuela Hofner, Christa Noehammer
Published in: International Journal of Molecular Sciences, Issue 26, 2025, Page(s) 6365, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms26136365

From Pharmaceutical to Biophysical Therapies: New Horizons in Inflammatory Bowel Disease Management

Author(s): Benedetta Ricchi, Alejandra A. Carriles, Samuel Elias Pineda Chavez, Stefanos Bonovas, Arianna Dal Buono, Cristina Bezzio, Alessandro Armuzzi, Stefania Vetrano
Published in: JCC Plus, Issue 1, 2026, ISSN 3066-943X
Publisher: Wiley
DOI: 10.1002/jcc5.70010

OMIP‐112: 42‐Parameter (40‐Color) Spectral Flow Cytometry Panel for Comprehensive Immunophenotyping of Human Peripheral Blood Leukocytes

Author(s): Laurien A. Waaijer, Bram van Cranenbroek, Hans J. P. M. Koenen
Published in: Cytometry Part A, Issue 107, 2026, Page(s) 226-232, ISSN 1552-4922
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cyto.a.24927

Development and validation of low-intensity pulsed ultrasound systems for highly controlled in vitro cell stimulation

Author(s): F. Fontana, F. Iberite, A. Cafarelli, A. Aliperta, G. Baldi, E. Gabusi, P. Dolzani, S. Cristino, G. Lisignoli, T. Pratellesi, E. Dumont, L. Ricotti
Published in: Ultrasonics, Issue 116, 2021, Page(s) 106495, ISSN 0041-624X
Publisher: Elsevier BV
DOI: 10.1016/j.ultras.2021.106495

Dynamic Changes in Extracellular Vesicle-Associated miRNAs Elicited by Ultrasound in Inflammatory Bowel Disease Patients

Author(s): Florian Tran, Alena Scharmacher, Nathan Baran, Neha Mishra, Marek Wozny, Samuel Pineda Chavez, Archana Bhardwaj, Sophia Hinz, Simonas Juzenas, Joana P. Bernardes, Laura Katharina Sievers, Matthias Lessing, Konrad Aden, Arne Lassen, Arne Bergfeld, Hauke Jann Weber, Lennart Neas, Stefania Vetrano, Stefan Schreiber, Philip Rosenstiel
Published in: scientific reports, 2024, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.21203/rs.3.rs-3999975/v1

Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease

Author(s): Mishra, Neha; Aden, Konrad; Blase, Johanna I.; Baran, Nathan; Bordoni, Dora; Tran, Florian; Conrad, Claudio; Avalos, Diana; Jaeckel, Charlot; Scherer, Michael; Sørensen, Signe B.; Overgaard, Silja H.; Schulte, Berenice; Nikolaus, Susanna; Rey, Guillaume; Gasparoni, Gilles; Lyons, Paul A.; Schultze, Joachim L.; Walter, Jörn; Andersen, Vibeke; Banos, Aggelos; Bertsias, George; Beyer, Marc; Boumpas
Published in: nlmid: 101475844, Issue 2, 2022, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/s13073-022-01112-z

ImmUniverse Consortium: Multi-omics integrative approach in personalized medicine for immune-mediated inflammatory diseases

Author(s): Stefania Vetrano, Gerben Bouma, Robert J. Benschop, Thomas Birngruber, Antonio Costanzo, G. R. A. M. D’Haens, Loredana Frasca, Rainer Hillenbrand, Lars Iversen, Claus Johansen, Arthur Kaser, Hans J. P. M. Koenen, Christa Noehammer, Laurent Peyrin-Biroulet, Jeroen Raes, Leonardo Ricotti, Philip Rosenstiel, Venkata P. Satagopam, Stefan Schreiber, Severine Vermeire, Andreas Wollenberg, Stephan Weid
Published in: Frontiers in Immunology, 2022, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.1002629

From tissue to blood: an integrated multi-omics signature identifies fibrogenesis and neutrophil activation as key drivers of ulcerative colitis severity

Author(s): E. Ozcariz, M. Ostaszewski, O. Lopata, L. Ciglar, A. Y. F. Li Yim, M. Pruijt, X. Wang, G. A. Vignolle, F. Tran, V. Satagopam, G. R. D’Haens, S. Schreiber, P. Rosenstiel, C. Nöhammer, K. Vierlinger
Published in: Frontiers in Immunology, Issue 17, 2026, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2026.1884480