Project description
A novel diagnostic test for lupus
Lupus is an autoimmune disease affecting millions of people worldwide. Diagnosis is often delayed as there is no specific diagnostic tool and most symptoms resemble those of other autoimmune diseases. To address this problem, the EU-funded ClarifyLupus project has developed a novel tool for the diagnosis of lupus. Unlike autoantibodies that are highly unspecific among diseases overlapping with lupus, ClarifyLupus employs a lupus-specific biomarker whose efficacy has been validated in blood samples. This breakthrough diagnostic tool is expected to facilitate early diagnosis, helping to avoid the irreversible damage of this devastating disease.
Objective
The difficulty on diagnosing lupus is due not only to the occurrence of overlapping symptoms with other autoimmune diseases but also to the unavailability of a lab test to confirm or rule out Lupus.
The autoimmune disease is devastating, and the later it is diagnosed, the worse are the irreversible damages to the patients. In the USA alone, there are 13.8M people with Lupus and overlapping diseases and 2,6M new cases of these diseases are diagnosed each year. These diseases affect more than 25M people in the EU.
We have developed a technology capable of identifying and quantifying altered proteins that play a key role in the onset of Lupus. Our product ClarifyLupus is a diagnostic test that is effective since the early stages of the disease.
Although our competitors are conducting research on Lupus biomarker discovery, they all are focused in autoantibodies biomarker discovery that are highly unspecific among Lupus-confounding diseases. In contrast we have a Lupus-specific biomarker that enables the Lupus diagnosis much earlier than our competitors.
We have passed the proof-of-concept stage where our diagnosis methodology was tested in blood samples and in January 2018 we have secured the Portuguese ethical committee approval to perform clinical assays, and are recruiting 50 patients until the end of the year.
In April 2018 we secured a Letter of Support from the Egas Moniz Hospital in Lisbon, stating the importance and market disruption of ClarifyLupus.
Clarify Analytical was founded in 2017 by Alexandra Antunes and João Rodrigues, two expert technologists in the fields of toxicology and mass spectroscopy, supported by 3 team members. The start-up was selected for the prestigious CoHiTech acceleration program in Portugal, focused on business and technology go-to-market. ClarifyLupus will be the breakthrough for Lupus diagnosis which will allow Lupus patients to be treated earlier, extending their lives by decades and improving their quality.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine rheumatology
- medical and health sciences basic medicine immunology autoimmune diseases
- natural sciences chemical sciences analytical chemistry mass spectrometry
- medical and health sciences basic medicine toxicology
- natural sciences physical sciences optics spectroscopy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.2.3. - INDUSTRIAL LEADERSHIP - Innovation In SMEs
MAIN PROGRAMME
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H2020-EU.3. - PRIORITY 'Societal challenges
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H2020-EU.2.1. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
SME-1 - SME instrument phase 1
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-EIC-SMEInst-2018-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
7000-872 EVORA
Portugal
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.