Molecular basis of human enhanceropathies

Deliverables

Documents, reports (1)

Detailed plan of dissemination and communication actions

Websites, patent fillings, videos etc. (2)

ENHPATHY's website V2.

V3 of the ENHPATHY public website including ESRs profiles

V1 of the public website and launch of the STED programme

V2 of the ENHPATHYs public website with link to the password secured intranet Social media accounts set up First press release V1 a digital brochure to summarize all communication tools and actions Launch of STED programme

Other (3)

Supervisory Board of the network

Supervisory Board operational

All organisational boards operational

All organisational boards are operational

"Start of the #EnhancerInArt programme"

Contact local cultural organizations and build a list of partnering artists Design develop and content editing of the ENHPATHYs blog A digital brochure of the EnhancerInArt is sent to cultural organizations

Publications

Peer reviewed articles (7)

Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness

Author(s): Pachano T, Sánchez-Gaya V, Ealo T, Mariner-Faulí M, Bleckwehl T, Asenjo HG, Respuela P, Cruz-Molina S, Muñoz-San Martín M, Haro E, van IJcken WFJ, Landeira D, Rada-Iglesias A
Published in: Nature Genetics, 2021, Page(s) 53(7):1036-1049, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-021-00888-x

Interplay between CTCF boundaries and a super enhancer controls cohesin extrusion trajectories and gene expression

Author(s): Vos ESM, Valdes-Quezada C, Huang Y, Allahyar A, Verstegen MJAM, Felder A-K, van der Vegt F, Uijttewaal ECH, Krijger PHL, and de Laat W
Published in: Nature Genetics, 2020, Page(s) 52, 1227-1238, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1016/j.molcel.2021.06.008

The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo

Author(s): Crispatzu G, Rehimi R, Pachano T, Bleckwehl T, Cruz-Molina S, Xiao C, Mahabir-Brenner E, Bazzi H, Rada-Iglesias A
Published in: Nature Communications, 2021, Page(s) 12(1):4344, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24641-4

Enhancer-associated H3K4 methylation safeguards in vitro germline competence

Author(s): Bleckwehl T, Crispatzu G, Schaaf K, Respuela P, Bartusel M, Benson L, Clark SJ, Dorighi KM, Barral A, Laugsch M, van IJcken WFJ, Manzanares M, Wysocka J, Reik W, Rada-Iglesias A
Published in: Nature Communications, 2021, Page(s) 12(1):5771., ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26065-6

Transcription factors: Bridge between cell signaling and gene regulation

Author(s): Paula Weidemüller, Maksim Kholmatov, Evangelia Petsalaki, Judith B Zaugg
Published in: PROTEOMICS, 2021, Page(s) 2021 Dec;21(23-24):e2000034, ISSN 1615-9853
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/pmic.202000034

Highly interconnected enhancer communities control lineage-determining genes in human mesenchymal stem cells

Author(s): Jesper G. S. Madsen, Maria S. Madsen, Alexander Rauch, Sofie Traynor, Elvira L. Van Hauwaert, Anders K. Haakonsson, Biola M. Javierre, Mette Hyldahl, Peter Fraser & Susanne Mandrup
Published in: Nature Genetics, 2020, Page(s) 52, 1227-1238, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-020-0709-z

Epromoters function as a hub to recruit key transcription factors required for the inflammatory response

Author(s): Santiago-Algarra D, Souaid C, Singh H, Dao LTM, Hussain S, Medina-Rivera A, Ramirez-Navarro L, Castro-Mondragon JA, Sadouni N, Charbonnier G, Spicuglia S
Published in: Nature Communications, 2021, Page(s) 18;12(1):6660, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26861-0