Training European Experts in Multiscale Studies of Neural Crest Development and Disorders: from Patient to Model Systems and Back again.

Project Information

NEUcrest

Grant agreement ID: 860635

DOI

10.3030/860635

Project closed

EC signature date 4 September 2019

Start date 1 November 2019

End date 30 April 2024

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 4 156 404,84

EU contribution

€ 4 156 404,84

Coordinated by

INSTITUT CURIE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (3)

Setup and composition of: Supervisory Board, Network Coordination Committee, Network selection committee, Young Scientists Committee, Ethics Committee, Scientific Advisory Board and IPR committee

The NEUcrest plan consists of six WPs three Research WPs WP13 Training WP4 CoordinationManagement WP5 and DisseminationOutreach WP6 Each WP is led by one of the academic partners with additional clinical or industrial coleads as appropriateTo run the ITN we will setup and fill the Supervisory Board Network Coordination Committee Network selection Committee Young Scientists Committee Scientific Advisory Board Intellectual Property Rights Committee and Ethics Committee M8 with relevant beneticiaries and partners

Report on already awarded PhDs

Report on already awarded PhDs (M48).

Final conference on Neural Crest Diseases

Final conference on neurocristopathies (M42)The final network meeting will be followed by an international two-three days conference organised by the ESRs under the title Neural crest in development and disease. International speakers will be invited and ESRs will also present their results orally and in poster sessions. At least one afternoon with patient groups will be organised, with help from the Eurordis European Network for Rare Diseases

Websites, patent fillings, videos etc. (1)

Wikipedia article

Wikipedia article (M27).NEUcrest ESRs will build an online encyclopaedia on neural crest cells and related-diseases in a collaborative way using a Wiki-based site. Contents quality will be monitored by ESR supervisors and Scientific Advisory Board (SAB) members. The short articles will have different versions corresponding to different target audiences: high school/general public, undergraduates/patient associations, PhD students/teachers/scientists

Publications

Peer reviewed articles (20)

Neural crest development and disorders: from patient to model system and back again – the NEUcrest conference.

Author(s): Marco Antonaci, Amy Kerr, Merin Lawrence, Francesca Lorenzini, Nitin Narwade, Chloé Paka, Anna Magdalena Wulf.
Published in: Biol Open, 2024, ISSN 2046-2441
Publisher: Royal Society Publishing
DOI: 10.1242/bio.060530

A 22q13.1 duplication in mosaicism including SOX10

Author(s): BERTANI-TORRES, W., Serey-Gaut, M., de Oliveira, J., Bole, C., Parisot, M., Nistschké, P., Maurin, M.-L., Lapierre, J.-M., Loundon, N., Belhous, K., Bondurand, N., Marlin, S., & Pingault, V
Published in: American Journal of Medical Genetics, 2023, ISSN 1096-8628
Publisher: Wiley
DOI: 10.1002/ajmg.a.63362

An efficient miRNA knockout approach using CRISPR-Cas9 in Xenopus

Author(s): Godden, Alice M.; Antonaci, Marco; Ward, Nicole J.; van der Lee, Michael; Abu-Daya, Anita; Guille, Matthew; Wheeler, Grant N.
Published in: Developmental Biology, Issue 2022 Mar, 483, 2021, Page(s) 66-75, ISSN 0012-1606
Publisher: Academic Press
DOI: 10.1016/j.ydbio.2021.12.015

Modelling 3D Tumour Microenvironment In Vivo: A Tool to Predict Cancer Fate

Author(s): Johanna Marines, Francesca Lorenzini, Karima Kissa, Laura Fontenille
Published in: Current Issues in Molecular Biology, Issue 45, 2023, Page(s) 9076-9083, ISSN 1467-3045
Publisher: ISSN National Centre for the UK
DOI: 10.3390/cimb45110569

Serotonin limits generation of chromaffin cells during adrenal organ development.

Author(s): Kameneva, P., Melnikova, V. I., Kastriti, M. E., Kurtova, A., Kryukov, E., Murtazina, A., Faure, L., Poverennaya, I., Artemov, A. V., Kalinina, T. S., Kudryashov, N. V., Bader, M., Skoda, J., Chlapek, P., Curylova, L., Sourada, L., Neradil, J., Tesarova, M., Pasqualetti, M., Gaspar, P., Yakushov, V.D., Sheftel, B.I., Zikmund, T., Kaiser, J., Fried, K., Alenina, N., Voronezhskaya, E.E., Adameyko, I
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-30438-w

A new atlas to study embryonic cell types in Xenopus.

Author(s): Petrova K, Tretiakov M, Kotov A, Monsoro-Burq AH, Peshkin L.
Published in: Dev Biol, 2024, ISSN 1759-7684
Publisher: John Wiley and Sons Ltd
DOI: 10.5281/zenodo.14012159

Insights Into the Early Gene Regulatory Network Controlling Neural Crest and Placode Fate Choices at the Neural Border

Author(s): Subham Seal, Anne H. Monsoro-Burq
Published in: Frontiers in Physiology, Issue 11, 2020, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.608812

SOX10: twenty years of phenotypic plurality and current understanding of its developmental function.

Author(s): Pingault V, Zerad L, BERTANI-TORRES W, and Bondurand N
Published in: Journal of Medical Genetics, 2021, ISSN 1096-8628
Publisher: Wiley
DOI: 10.1136/jmedgenet-2021-108105

Waardenburg syndrome: contribution of next-generation sequencing to the identification of novel causative variants.

Author(s): BERTANI-TORRES W, Lezirovitz K, Coutinho DA, Pardono E, Costa SS, Antunes LN, de Oliveira J, Otto PA, Pingault V, Mingroni-Netto RC
Published in: Audiology Research, 2023, ISSN 2039-4349
Publisher: Basel MDPI
DOI: 10.3390/audiolres14010002

Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with WNT/planar cell polarity dysregulation

Author(s): Mohammad Alhashmi, Abdulrahman ME Gremida, Santosh K Maharana, Marco Antonaci, Amy Kerr, Noor A Al-Maslamani, Ke Liu, Maria M Meschis, Hazel Sutherland, Peter Wilson, Peter Clegg, Grant N Wheeler, Robert J van ’t Hof, George Bou-Gharios, Kazuhiro Yamamoto
Published in: bioRxiv, 2024, ISSN 2692-8205
Publisher: CSHL
DOI: 10.1101/2023.07.11.548556

Determining miRNA Expression Patterns in Xenopus.

Author(s): Antonaci M, Godden AM, Wheeler GN
Published in: Methods in Molecular Biology, 2023, Page(s) 145-154, ISSN 1940-6029
Publisher: Clifton, N.J.Online
DOI: 10.5281/zenodo.14046899

scEvoNet: a gradient boosting-based method for prediction of cell state evolution.

Author(s): Kotov A, Zinovyev A, Monsoro-Burq AH.
Published in: BMC Bioinformatics, 2023, ISSN 1471-2105
Publisher: BioMed Central
DOI: 10.1186/s12859-023-05213-3

Two induced pluripotent stem cell (iPSC) lines derived from patients affected by Waardenburg syndrome type 1 retain potential to activate neural crest markers.

Author(s): Alkobtawi A, Pla P, Onteniente B, Seal S, Pingault V, Marlin S, Monsoro-Burq AH
Published in: Stem Cell Research, 2023, ISSN 1873-5061
Publisher: Elsevier
DOI: 10.1016/j.scr.2023.103074

Generation of an iPSC line (IMAGINi022-A) from a patient carrying a SOX10 missense mutation and presenting with deafness, depigmentation and progressive neurological impairment

Author(s): Celine Banal, Eddy Quelennec, William Bertani-Torres, Nadjet Gacem, Jeanne Amiel, Sandrine Marlin, Florence Petit, Veronique Pingault, Nathalie Lefort, Nadege Bondurand
Published in: Stem Cell Research, 2020, Page(s) 101936, ISSN 1873-5061
Publisher: Elsevier
DOI: 10.1016/j.scr.2020.101936

Two distinct epithelial-to-mesenchymal transition programs control invasion and inflammation in segregated tumor cell populations

Author(s): Khalil Kass Youssef, Nitin Narwade, Aida Arcas, Angel Marquez-Galera, Raúl Jiménez-Castaño, Cristina Lopez-Blau, Hassan Fazilaty, David García-Gutierrez, Amparo Cano, Joan Galcerán, Gema Moreno-Bueno, Jose P. Lopez-Atalaya, M. Angela Nieto
Published in: Nature Cancer, 2024, ISSN 2662-1347
Publisher: Online
DOI: 10.1038/s43018-024-00839-5

MicroRNAs in neural crest development and neurocristopathies

Author(s): Marco Antonaci , Grant N Wheeler
Published in: Biochem Soc Trans, 2022, ISSN 1470-8752
Publisher: Biochemical Society Portland Press
DOI: 10.1042/bst20210828

A time-resolved single-cell roadmap of the logic driving anterior neural crest diversification from neural border to migration stages

Author(s): Aleksandr Kotov, Subham Seal, Mansour Alkobtawi, Vincent Kappès, Sofia Medina Ruiz, Hugo Arbès, Richard Harland, Leonid Peshkin, and Anne H. Monsoro-Burq 2024 May 7;121(19):e2311685121. doi: 10.1073/pnas.2311685121. Epub 2024 Apr 29. PMID: 38683994; PMCID: PMC11087755. Format:
Published in: Proc Natl Acad Sci U S A., Issue 2024 May 7;121(19):e2311685121, 2024, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.5281/zenodo.14002985

A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology.

Author(s): Petersen, J., Englmaier, L., Artemov, A. V., Poverennaya, I., Mahmoud, R., Bouderlique, T., Tesarova, M., Deviatiiarov, R., Szilvásy-Szabó, A., Akkuratov, E. E., Pajuelo Reguera, D., Zeberg, H., Kaucka, M., Kastriti, M. E., Krivanek, J., Radaszkiewicz, T., Gömöryová, K., Knauth, S., Potesil, D., Zdrahal, Z., Ganji,, R.S., Grabowski, A., Buhl, M.E., Zikmund, T., Kavkova, M., Axelson, H., Lindg
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-38663-7

Motor innervation directs the correct development of the mouse sympathetic nervous system

Author(s): Alek G. Erickson, Alessia Motta, Maria Eleni Kastriti, Steven Edwards, Fanny Coulpier, Emy Théoulle, Aliia Murtazina, Irina Poverennaya, Daniel Wies, Jeremy Ganofsky, Giovanni Canu, Francois Lallemend, Piotr Topilko, Saida Hadjab, Kaj Fried, Christiana Ruhrberg, Quenten Schwarz, Valerie Castellani, Dario Bonanomi, Igor Adameyko
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-51290-0

Defining Pathological Activities of ALK in Neuroblastoma, a Neural Crest-Derived Cancer

Author(s): Wulf, Anna W.; Moreno, Marcela M.; Paka, Chloé; Rampasekova, Alexandra; Liu, Karen J.
Published in: International journal of molecular sciences, 2021, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222111718

Other (1)

Modelling 3D tumour microenvironment in a melanoma zebrafish model using live imaging technique: a tool to predict cancer fate

Author(s): Lorenzini, Francesca; Marines, Johanna; Kissa, Karima; Fontenille, Laura
Published in: 2021
Publisher: bioRxiv
DOI: 10.1101/2021.09.23.461461

Book chapters (2)

Differentiation of human induced pluripotent stem cells to the neural crest lineage.

Author(s): Paka, C. A., Barrell, W. B., Monsoro-Burq, A. H., and Liu, K. J.
Published in: Current Progress in iPSC-derived Cell Types, Volume 10, 2021, Page(s) 117-147
Publisher: Elsevier Inc.
DOI: 10.5281/zenodo.14019009

An efficient CRISPR-Cas9 method to knockout and rescue miRNA expression in Xenopus tropicalis

Author(s): Alice M. Godden, Marco Antonaci & Grant N. Wheeler
Published in: Methods in Molecular Biology, MicroRNA Detection and Target Identification, 2023, Page(s) 231-241
Publisher: Springer US
DOI: 10.5281/zenodo.14046864

Non-peer reviewed articles (1)

Melanoma innervation is associated with cancer progression in a zebrafish xenograft model.

Author(s): Lorenzini F, Marines J, Le Friec J, Do Khoa N, Nieto M A, Sanchez-Laorden B, Mione M C, Kissa K, Fontenille L.
Published in: bioRxiv, 2023, ISSN 2692-8205
Publisher: Online
DOI: 10.1101/2023.12.13.571512