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FLow chemistry for Isotopic eXchange

Deliverables

Innovative isotopic sources (initial)

New efficient and safer isotopic exchange for 1H/2H and 12C/13C isotope exchange which can be used either for batch and flow chemistry and are consistent with a specific and selective isotopic exchange.

New nanoparticle catalysts for isotopic exchange (initial)

New nanoparticle catalysts (initial) for batch/flow 1H/2H and 12C/13C exchange with high specificities and selectivities. Thes catalysts are decorated nanopartcles which can also be adsorbed on different supports (see heterogeneous catalysts).

Basic modules for flow 1H/2H exchange

"Basic modules for flow 1H/2H exchange containing either commercial or ""standard"" catalysts already used by partners. They will be used as a proof of concept of the FLIX-CAT paradigm. "

Basic modules for flow 12C/13C exchange

"Basic modules for flow 12C/13C exchange containing either commercial or ""standard"" catalysts already used by partners. hey will be used as a proof of concept of the FLIX-CAT paradigm. "

Website and Logo

Information about project website, logo and communication accounts (Twitter page, etc.).

Publications

Nanocatalyzed Hydrogen Isotope Exchange

Author(s): Marco Lepron, Marion Daniel-Bertrand, Gabriel Mencia, Bruno Chaudret, Sophie Feuillastre, Grégory Pieters
Published in: Accounts of Chemical Research, 2021, ISSN 0001-4842
DOI: 10.1021/acs.accounts.0c00721

Photochemical Strategy for Carbon Isotope Exchange with CO 2

Author(s): Victor Babin, Alex Talbot, Alexandre Labiche, Gianluca Destro, Antonio Del Vecchio, Charles S. Elmore, Frédéric Taran, Antoine Sallustrau, Davide Audisio
Published in: ACS Catalysis, Issue 11/5, 2021, Page(s) 2968-2976, ISSN 2155-5435
DOI: 10.1021/acscatal.0c05344

Manganese-catalyzed selective C–H activation and deuteration by means of a catalytic transient directing group strategy

Author(s): Sara Kopf, Helfried Neumann, Matthias Beller
Published in: Chemical Communications, Issue 57/9, 2021, Page(s) 1137-1140, ISSN 1359-7345
DOI: 10.1039/d0cc07675a

A Nickel(II)‐Mediated Thiocarbonylation Strategy for Carbon Isotope Labeling of Aliphatic Carboxamides

Author(s): Simon S. Pedersen, Aske S. Donslund, Jesper H. Mikkelsen, Oskar S. Bakholm, Florian Papp, Kim B. Jensen, Magnus B. F. Gustafsson, Troels Skrydstrup
Published in: Chemistry – A European Journal, 2021, ISSN 0947-6539
DOI: 10.1002/chem.202005261