European Commission logo
English English
CORDIS - EU research results
CORDIS

FLow chemistry for Isotopic eXchange

Deliverables

Innovative isotopic sources (final)

New efficient and safer isotopic sources usable for 1H2H 12C13C and 14N15N isotope exchange in the FLIXBOX environment with an assessment in terms of efficiency and safety relative to standard isotope sources

Updated Risk Management Plan (RP2)

Updated Risk Management Plan based on previous results experience and encountered issues according to SB decisions and AB remarks avise and suggestions

Innovative isotopic sources (initial)

New efficient and safer isotopic exchange for 1H/2H and 12C/13C isotope exchange which can be used either for batch and flow chemistry and are consistent with a specific and selective isotopic exchange.

New nanoparticle catalysts for isotopic exchange (initial)

New nanoparticle catalysts (initial) for batch/flow 1H/2H and 12C/13C exchange with high specificities and selectivities. Thes catalysts are decorated nanopartcles which can also be adsorbed on different supports (see heterogeneous catalysts).

Basic modules for flow 1H/2H exchange

"Basic modules for flow 1H/2H exchange containing either commercial or ""standard"" catalysts already used by partners. They will be used as a proof of concept of the FLIX-CAT paradigm. "

Basic modules for flow 12C/13C exchange

"Basic modules for flow 12C/13C exchange containing either commercial or ""standard"" catalysts already used by partners. hey will be used as a proof of concept of the FLIX-CAT paradigm. "

M2 Meeting

M2 Meeting report including agenda list of participants minutes pictures ERs and ESRs presentations AB remarks and decisions taken during this consortium meeting This document will serve as proof and guidelines for implementation of decisions made by the SB

M1 Meeting

M1 Meeting report including agenda list of participants minutes pictures ERs and ESRs presentations AB remarks and decisions taken during this consortium meeting This document will serve as proof and guidelines for implementation of decisions made by the SB

New nanoparticle catalysts for isotope exchange (final)

New metal nanoparticle catalysts usable for continuous flow 1H2H 12C13C and 14N15N isotope exchange selected on the basis of robustness tests efficiency specificity selectivity metal leaching catalyst resistance and compatibility with flow chemistry conditions and process

Website and Logo

Information about project website, logo and communication accounts (Twitter page, etc.).

Publications

Nanocatalyzed Hydrogen Isotope Exchange

Author(s): Marco Lepron, Marion Daniel-Bertrand, Gabriel Mencia, Bruno Chaudret, Sophie Feuillastre, Grégory Pieters
Published in: Accounts of Chemical Research, 2021, ISSN 0001-4842
Publisher: American Chemical Society
DOI: 10.1021/acs.accounts.0c00721

Photochemical Strategy for Carbon Isotope Exchange with CO 2

Author(s): Victor Babin, Alex Talbot, Alexandre Labiche, Gianluca Destro, Antonio Del Vecchio, Charles S. Elmore, Frédéric Taran, Antoine Sallustrau, Davide Audisio
Published in: ACS Catalysis, Issue 11/5, 2021, Page(s) 2968-2976, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.0c05344

Manganese‐Catalysed Deuterium Labelling of Anilines and Electron‐Rich (Hetero)Arenes

Author(s): Florian Bourriquen; Nils Rockstroh; Stephan Bartling; Kathrin Junge; Matthias Beller
Published in: Wiley Online Library, Issue 9, 2021, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1002/ange.202202423

Late-Stage Carbon-14 Labeling and Isotope Exchange: Emerging Opportunities and Future Challenges

Author(s): Victor Babin; Frédéric Taran; Davide Audisio
Published in: Jacs Au, Issue 11, 2022, ISSN 1520-5126
Publisher: American Chemical Society
DOI: 10.1021/jacsau.2c00030

Parallel Screening with <sup>14</sup> C‐Labeled Carbon Dioxide: De‐risking the Staudinger‐Aza‐Wittig Reaction**

Author(s): Victor Babin; Antoine Sallustrau; Maxime Molins; Alexandre Labiche; Amélie Goudet; Frédéric Taran; Davide Audisio
Published in: European Journal of Organic Chemistry, Issue 6, 2022, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.202200133

Direct Carbon Isotope Exchange of Pharmaceuticals via Reversible Decyanation

Author(s): Minghao Feng; Joao De Oliveira; Antoine Sallustrau; Gianluca Destro; Pierre Thuéry; Sebastien Roy; Thibault Cantat; Charles S. Elmore; Jorg Blankenstein; Frédéric Taran; Davide Audisio
Published in: Journal of the American Chemical Society, Issue 15, 2021, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c01923

Dual role of benzophenone enables a fast and scalable C-4 selective alkylation of pyridines in flow

Author(s): Jesús Sanjosé-Orduna; Rodrigo C. Silva; Fabian Raymenants; Bente Reus; Jannik Thaens; Kleber T. de Oliveira; Timothy Noël
Published in: Chemical Science, Issue 4, 2022, ISSN 2041-6539
Publisher: Chemical Science
DOI: 10.1039/d2sc04990b

Manganese-catalyzed selective C–H activation and deuteration by means of a catalytic transient directing group strategy

Author(s): Sara Kopf, Helfried Neumann, Matthias Beller
Published in: Chemical Communications, Issue 57/9, 2021, Page(s) 1137-1140, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cc07675a

Nickel-Mediated Alkoxycarbonylation for Complete Carbon Isotope Replacement.

Author(s): Stephanie J. Ton; Karoline T. Neumann; Peter Nørby; Troels Skrydstrup
Published in: Chemical Europe Journal, Issue 7, 2021, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1021/jacs.1c09170

A Nickel(II)‐Mediated Thiocarbonylation Strategy for Carbon Isotope Labeling of Aliphatic Carboxamides

Author(s): Simon S. Pedersen, Aske S. Donslund, Jesper H. Mikkelsen, Oskar S. Bakholm, Florian Papp, Kim B. Jensen, Magnus B. F. Gustafsson, Troels Skrydstrup
Published in: Chemistry – A European Journal, 2021, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202005261

Copper-catalysed low-temperature water-gas shift reaction for selective deuteration of aryl halides

Author(s): Wu Li; Ruiyang Qu; Weiping Liu; Florian Bourriquen; Stephan Bartling; Nils Rockstroh; Kathrin Junge; Matthias Beller
Published in: Chemical Science, Issue 10, 2021, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1sc04259a

Easy-to-Implement Hydrogen Isotope Exchange for the Labeling of <i>N</i>-Heterocycles, Alkylkamines, Benzylic Scaffolds, and Pharmaceuticals

Author(s): Etienne Levernier; Kevin Tatoueix; Sébastien Garcia-Argote; Viktor Pfeifer; Ralf Kiesling; Edmond Gravel; Sophie Feuillastre; Grégory Pieters
Published in: Journal access of the American Chemical Society, Issue 2, 2022, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacsau.1c00503

Base‐Mediated Remote Deuteration of N ‐Heteroarenes – Broad Scope and Mechanism

Author(s): Sara Kopf; Jiali Liu; Robert Franke; Haijun Jiao; Helfried Neumann; Matthias Beller
Published in: European Journal of Organic Chemistry, Issue 4, 2022, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.202200204

Recent Developments for the Deuterium and Tritium Labeling of Organic Molecules

Author(s): Sara Kopf; Florian Bourriquen; Wu Li; Helfried Neumann; Kathrin Junge; Matthias Beller
Published in: Chemical Reviews, Issue 1, 2022, ISSN 1520-6890
Publisher: Chemical Review
DOI: 10.1021/acs.chemrev.1c00795

Ruthenium-Catalyzed Deuteration of Aromatic Carbonyl Compounds with a Catalytic Transient Directing Group.

Author(s): Sara Kopf; Fei Ye; Fei Ye; Helfried Neumann; Matthias Beller
Published in: Chemistry, Issue 2, 2021, ISSN 1521-3765
Publisher: Wiley VCH
DOI: 10.1002/chem.202100468

Searching for OpenAIRE data...

There was an error trying to search data from OpenAIRE

No results available