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Inhalable Aerosol Light Source for Controlling Drug-Resistant Bacterial Lung Infections

Project description

Novel treatment of drug-resistant bacterial lung infections

The growing resistance to many antibiotics and the emergence of multidrug-resistant bacteria calls for the development of alternative antibacterial therapies. Currently, bacterial drug resistance is the leading cause of morbidity and mortality in patients with cystic fibrosis and hospital-acquired lung infections. The EU-funded project will develop new treatment for bacterial lung infections using inhalable light sources that excite bacterial endogenous photosensitisers (porphyrins), killing the bacteria via the photodynamic effect (local production of reactive cytotoxic oxygen). The treatment will be safe for host tissues and effective against drug-resistant pathogens. Research involves the development of inhalable luminescent particles, the method for delivery to the lungs, and evaluation of the treatment parameters in relevant clinical models.

Field of science

  • /natural sciences/biological sciences/microbiology/bacteriology
  • /engineering and technology/nanotechnology
  • /medical and health sciences/medical biotechnology/nanomedicine
  • /social sciences/sociology/demography/mortality
  • /natural sciences/physical sciences/theoretical physics/particles
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/multidrug resistance
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/antibiotic resistance

Call for proposal

H2020-FETOPEN-2018-2019-2020-01
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

INSTITUT QUIMIC DE SARRIA
Address
Calle Via Augusta 384-394
08017 Barcelona
Spain
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 714 375

Participants (7)

UNIVERSITA DEGLI STUDI DI FIRENZE
Italy
EU contribution
€ 593 125
Address
Piazza San Marco 4
50121 Florence
Activity type
Higher or Secondary Education Establishments
SORBONNE UNIVERSITE
France
EU contribution
€ 294 250
Address
21 Rue De L'ecole De Medecine
75006 Paris
Activity type
Higher or Secondary Education Establishments
FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA
Spain
EU contribution
€ 372 500
Address
Avenida Paissos Catalans 16
43007 Tarragona
Activity type
Research Organisations
UNIVERSITA DEGLI STUDI DI PADOVA
Italy
EU contribution
€ 410 000
Address
Via 8 Febbraio 2
35122 Padova
Activity type
Higher or Secondary Education Establishments
CARDIFF SCINTIGRAPHICS LIMITED
United Kingdom
EU contribution
€ 336 875
Address
Cardiff Medicentre, Heath Park
CF14 4UJ Cardiff
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE UNIVERSITY OF LIVERPOOL
United Kingdom
EU contribution
€ 532 500
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Activity type
Higher or Secondary Education Establishments
WEDO PROJECT INTELLIGENCE MADE EASY SL
Spain
EU contribution
€ 240 000
Address
Calle Rossello 248, Planta 5, Puerta 2
08008 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)