Biomechanical biomarkers for predicting immunotherapy response
Cancer immunotherapy causes severe toxicities in some cases, underscoring the importance of biomarkers that can predict non-responders in a timely manner. To address this issue, the EU-funded Immuno-Predictor project is working under the hypothesis that certain biomechanical aspects of the tumour microenvironment, such as tumour stiffness, solid stress, perfusion and hypoxia, are responsible for the resistance to immunotherapy. Systemic administration of immunotherapy requires a well-perfused vascular system, and that is often not the case in stiff and hypoxic tumours. Using clinically applied, ultrasound-based methods and computational biomechanical modelling in tumour-bearing mice and cancer patients, Immuno-Predictor scientists will identify biomechanical biomarkers to predict immunotherapy outcome.
Fields of science
Funding SchemeERC-COG - Consolidator Grant
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