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NUMERICAL MODELLING OF HEMODYNAMICS AND PHARMACOKINETICS FOR CLINICAL TRANSLATION

Project description

A haemodynamic model for surgical planning

Surgical interventions are based on patient data, and although they require careful planning, they may be revised during surgery. To better predict surgery outcome, several aspects must be considered, including the local point of intervention, whole organ perfusion and function as well as their interaction with the entire circulation. To address this complexity, the EU-funded MoDeLLiver project aims to develop a haemodynamic model to guide surgical interventions in the lung and liver. Researchers will also employ an injected substance model to unravel the link between non-invasive medical imaging and organ perfusion and function: this will be very useful to parameterise the model prior to the patient's intervention. The new modelling tool is expected to bring personalised surgical simulation a step closer to reality.

Objective

Surgical interventions often require vascular procedures consisting in cutting vessels, removing organ parts or suturing new connections. Intervention planning is based on patient data and surgeons experience. Even the best plans are often revised in real-time during surgery. Can we understand and predict blood flow changes due to a surgery? Complex interactions must be foreseen between three scales: the local point of intervention, whole organ perfusion and function, and the entire circulation. Such complexity calls for modelling and simulation, which should become part of the surgical decision process.
Yet, the modelling community does not sufficiently respond to these challenges. Despite great advances in blood flow simulation, clinical translation remains largely unfulfilled, as existing tools are too heavy, pathological interactions complex and multidisciplinary collaboration uneasy. Organ interactions and remodelling due to surgery or diseases are missing from comprehensive models. Besides, simulations must be based on patient data, ideally non-invasive ones. Despite great advances in dynamic imaging, the link between signal and underlying tissue perfusion and function remains to be elucidated, beyond current pharmacokinetics models. Their better understanding will bring new data for personalised simulation.
Our ambition is to gear hemodynamics modelling towards diseased organs to guide associated surgical acts, focusing on lung and liver. We will investigate a novel approach of an injected substance model transported through the cardiovascular system; i.e. enhancing pharmacokinetics modelling by transport phenomena based on hemodynamics. Numerical simulations of such models will unravel the interplay between architecture, perfusion and function in diseased organs, and provide peri- & peroperative guiding information. This project will impact bioengineering, pathophysiology, dynamic imaging, and surgery through the final aim of software clinical translation.

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Coordinator

INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET AUTOMATIQUE
Net EU contribution
€ 1 991 817,50
Address
Domaine de voluceau rocquencourt
78153 Le chesnay cedex
France

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Region
Ile-de-France Ile-de-France Yvelines
Activity type
Research Organisations
Links
Other funding
€ 0,00

Beneficiaries (1)