Protein phosphatase 1-disrupting peptides: Scope and mechanism of action in the treatment of heart insufficiency

Project Information

PDPcardio

Grant agreement ID: 865119

DOI 10.3030/865119

EC signature date 15 January 2020

Start date 1 February 2020

End date 31 January 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 998 750,00

EU contribution € 1 998 750,00

Coordinated by

ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Germany

Publications

Peer reviewed articles (6)

Exploring Uncharted Territory: Toward Metabolite Network Maps

Author(s): Eva-Maria Dürr, Maja Köhn
Published in: ACS Central Science, Issue 8, 2022, Page(s) 1576-1578, ISSN 2374-7943
Publisher: American Chemical Society
DOI: 10.1021/acscentsci.2c01435

Turn and Face the Strange: A New View on Phosphatases

Author(s): Maja Köhn
Published in: ACS Central Science, Issue 6/4, 2020, Page(s) 467-477, ISSN 2374-7943
Publisher: PMC
DOI: 10.1021/acscentsci.9b00909

Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A

Author(s): Bernhard Hoermann, Thomas Kokot, Dominic Helm, Stephanie Heinzlmeir, Jeremy E. Chojnacki, Thomas Schubert, Christina Ludwig, Anna Berteotti, Nils Kurzawa, Bernhard Kuster, Mikhail M. Savitski, Maja Köhn
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17334-x

Towards Dissecting the Mechanism of Protein Phosphatase‐1 Inhibition by Its C ‐Terminal Phosphorylation

Author(s): Francesca Salvi, Bernhard Hoermann, Javier Pino García, Miriam Fontanillo, Rita Derua, Monique Beullens, Mathieu Bollen, Orsolya Barabas, Maja Köhn
Published in: ChemBioChem, Issue 22/5, 2021, Page(s) 834-838, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202000669

Short peptide pharmacophores developed from protein phosphatase-1 disrupting peptides (PDPs)

Author(s): Miriam Fontanillo; Malgorzata Trebacz; Christopher D. Reinkemeier; Daniela Avilés Huerta; Ulrike Uhrig; Peter Sehr; Maja Köhn
Published in: Bioorganic and Medicinal Chemistry, Issue 09680896, 2022, Page(s) 116785, ISSN 0968-0896
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2022.116785

Evolutionary crossroads of cell signaling: PP1 and PP2A substrate sites in intrinsically disordered regions

Author(s): Bernhard Hoermann, Maja Köhn
Published in: Biochemical Society Transactions, Issue 49/3, 2021, Page(s) 1065-1074, ISSN 0300-5127
Publisher: Portland Press, Ltd.
DOI: 10.1042/bst20200175

Book chapters (1)

PLDMS: Phosphopeptide Library Dephosphorylation Followed by Mass Spectrometry Analysis to Determine the Specificity of Phosphatases for Dephosphorylation Site Sequences

Author(s): Thomas Kokot, Bernhard Hoermann, Dominic Helm, Jeremy E. Chojnacki, Mikhail M. Savitski, Maja Köhn
Published in: Methods in Molecular Biology, 2022, Page(s) 43-64, ISBN 978-1-0716-2317-6
Publisher: Humana
DOI: 10.1007/978-1-0716-2317-6_2