Protein phosphatase 1-disrupting peptides: Scope and mechanism of action in the treatment of heart insufficiency

Project Information

PDPcardio

Grant agreement ID: 865119

DOI

10.3030/865119

EC signature date 15 January 2020

Start date 1 February 2020

End date 31 January 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 998 750,00

EU contribution

€ 1 998 750,00

Coordinated by

RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

Exploring Uncharted Territory: Toward Metabolite Network Maps

Author(s): Eva-Maria Dürr, Maja Köhn
Published in: ACS Central Science, Issue 8, 2022, Page(s) 1576-1578, ISSN 2374-7943
Publisher: American Chemical Society
DOI: 10.1021/acscentsci.2c01435

Turn and Face the Strange: A New View on Phosphatases

Author(s): Maja Köhn
Published in: ACS Central Science, Issue 6/4, 2020, Page(s) 467-477, ISSN 2374-7943
Publisher: PMC
DOI: 10.1021/acscentsci.9b00909

A strategy to disentangle direct and indirect effects on (de)phosphorylation by chemical modulators of the phosphatase PP1 in complex cellular contexts

Author(s): Bernhard Hoermann, Eva-Maria Dürr, Christina Ludwig, Melda Ercan, Maja Köhn
Published in: Chemical Science, Issue 15, 2024, Page(s) 2792-2804, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3sc04746f

A Modular Approach for the Synthesis of Diverse Heterobifunctional Cyanine Dyes

Author(s): Corina Maller, Franziska Schedel, Maja Köhn
Published in: The Journal of Organic Chemistry, Issue 89, 2024, Page(s) 3844-3856, ISSN 0022-3263
Publisher: American Chemical Society
DOI: 10.1021/acs.joc.3c02673

Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A

Author(s): Bernhard Hoermann, Thomas Kokot, Dominic Helm, Stephanie Heinzlmeir, Jeremy E. Chojnacki, Thomas Schubert, Christina Ludwig, Anna Berteotti, Nils Kurzawa, Bernhard Kuster, Mikhail M. Savitski, Maja Köhn
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17334-x

Towards Dissecting the Mechanism of Protein Phosphatase‐1 Inhibition by Its C ‐Terminal Phosphorylation

Author(s): Francesca Salvi, Bernhard Hoermann, Javier Pino García, Miriam Fontanillo, Rita Derua, Monique Beullens, Mathieu Bollen, Orsolya Barabas, Maja Köhn
Published in: ChemBioChem, Issue 22/5, 2021, Page(s) 834-838, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202000669

Photo‐Claisen Rearrangement in a Coumarin‐Caged Peptide leads to a Surprising Enzyme Hyperactivation

Author(s): Corina Maller, Eirini Marouda, Maja Köhn
Published in: ChemBioChem, 2024, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202400561

Short peptide pharmacophores developed from protein phosphatase-1 disrupting peptides (PDPs)

Author(s): Miriam Fontanillo; Malgorzata Trebacz; Christopher D. Reinkemeier; Daniela Avilés Huerta; Ulrike Uhrig; Peter Sehr; Maja Köhn
Published in: Bioorganic and Medicinal Chemistry, Issue 09680896, 2022, Page(s) 116785, ISSN 0968-0896
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2022.116785

Evolutionary crossroads of cell signaling: PP1 and PP2A substrate sites in intrinsically disordered regions

Author(s): Bernhard Hoermann, Maja Köhn
Published in: Biochemical Society Transactions, Issue 49/3, 2021, Page(s) 1065-1074, ISSN 0300-5127
Publisher: Portland Press, Ltd.
DOI: 10.1042/bst20200175

Book chapters (1)

PLDMS: Phosphopeptide Library Dephosphorylation Followed by Mass Spectrometry Analysis to Determine the Specificity of Phosphatases for Dephosphorylation Site Sequences

Author(s): Thomas Kokot, Bernhard Hoermann, Dominic Helm, Jeremy E. Chojnacki, Mikhail M. Savitski, Maja Köhn
Published in: Methods in Molecular Biology, 2022, Page(s) 43-64, ISBN 978-1-0716-2317-6
Publisher: Humana
DOI: 10.1007/978-1-0716-2317-6_2