Project description DEENESFRITPL 3D temperature mapping critical to understanding the nanoworld Nanometre-scale devices capable of measuring temperature variations at a molecular level are valuable in both fundamental and applied science. For example, they can quickly measure micromachine overheating or the temperature inside of a cell. Although they hold tremendous promise for many applications, their 2D resolution has been a limiting factor against their more widespread use. The EU-funded ThermoRise project will provide a route against this barrier by developing local nanoprobes with tailored magnetic properties that will record critical information about local temperature in 3D. In particular, the nanoprobes will record the most relevant temperature information instead of reading the present temperature value. The project's achievements will widen the range of applications of nanothermometers, allowing temperature measurement in confined environments and in non-transparent media. Show the project objective Hide the project objective Objective The last decades witnessed a quest for devices responding to temperature at a distance with unprecedented space resolution, approaching the nanoscale. Such devices are valuable in both fundamental and applied science, from overheat in micromachines to hyperthermia applied to cells. Despite great advances, the response is still collected in 2D. In real systems, heat flows in 3 dimensions such that 2D nanothermometers give just a plane view of a 3D reality. The restriction to 2D emerges because space resolution is bound to time and temperature resolutions, leading to a trilemma: scanning into the 3rd dimension is time consuming and cannot be achieve without losing temperature and time resolutions. While incremental improvements have been achieved in recent years, adding the 3rd dimension to nanothermometry is crucial for further impact and requires an innovative approach. Herein, I propose the development of nano local probes with tailored magnetic properties recording critical information about local temperature in 3D. These thermometric local probes avoid the resolution trilemma by recording the most relevant temperature information instead of reading the present temperature value. In many applications, including cellular hyperthermia, most part of the current temperature reading is of minor relevance and can be dropped. The key temperature information includes the maximum temperature achieved, the surpass of a given temperature threshold, and the time elapsed after this surpass. Once recorded, this key information can be read in 3D by standard devices (such as confocal microscopes and magnetic resonance imaging scanners) without time constrains and thus keeping a high space and temperature resolution. Moreover, the reading step can be performed in-situ and/or ex-situ, decoupling probes and reading devices if needed. This widens the range of applications of nanothermometers, allowing detection in confined environments and in non-transparent media. Fields of science natural sciencesphysical sciencesopticsmicroscopyconfocal microscopyengineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imaging Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Topic(s) ERC-2019-COG - ERC Consolidator Grant Call for proposal ERC-2019-COG See other projects for this call Funding Scheme ERC-COG - Consolidator Grant Coordinator UNIVERSIDADE DE AVEIRO Net EU contribution € 1 988 353,75 Address Campus universitário de santiago 3810-193 Aveiro Portugal See on map Region Continente Centro (PT) Região de Aveiro Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Beneficiaries (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSIDADE DE AVEIRO Portugal Net EU contribution € 1 988 353,75 Address Campus universitário de santiago 3810-193 Aveiro See on map Region Continente Centro (PT) Região de Aveiro Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
