Resurrecting the Carboxyl Polyether Ionophores

Project Information

RECYPION

Grant agreement ID: 865738

DOI

10.3030/865738

Project closed

EC signature date 19 February 2020

Start date 1 March 2020

End date 31 August 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 998 864,00

EU contribution

€ 1 998 864,00

Coordinated by

AARHUS UNIVERSITET
Denmark

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

The Biological Activities of Polyether Ionophore Antibiotic Routiennocin is Independent of Absolute Stereochemistry

Author(s): Søren Lau Borcher Møller, Michelle H. Rasmussen, Jun Li, Esben B. Svenningsen, Gustav J. Wørmer, Thomas Tørring, Thomas B. Poulsen
Published in: ChemBioChem, Issue 25, 2024, Page(s) e202400013, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202400013

Ionophore antibiotic X-206 is a potent inhibitor of SARS-CoV-2 infection in vitro

Author(s): Esben B. Svenningsen, Jacob Thyrsted, Julia Blay-Cadanet, Han Liu, Shaoquan Lin, Jaime Moyano-Villameriel, David Olagnier, Manja Idorn, Søren R. Paludan, Christian K. Holm, Thomas B. Poulsen
Published in: Antiviral Research, Issue 185, 2021, Page(s) 104988, ISSN 0166-3542
Publisher: Elsevier BV
DOI: 10.1016/j.antiviral.2020.104988

Polyether Ionophore Antibiotics Target Drug-Resistant Clinical Isolates, Persister Cells, and Biofilms

Author(s): Malene Wollesen, Kasper Mikkelsen, Marie Selch Tvilum, Martin Vestergaard, Mikala Wang, Rikke L. Meyer, Hanne Ingmer, Thomas B. Poulsen, Thomas Tørring
Published in: Microbiology Spectrum, Issue 11, 2023, Page(s) e00625-23, ISSN 2165-0497
Publisher: ASM Journals
DOI: 10.1128/spectrum.00625-23

P450 Enzyme LyoI Performs Hydro‐2,2′‐Bifuran Oxidation in the Polyether Ionophore Lysocellin

Author(s): Michelle H. Rasmussen, Søren L. B. Møller, Esben B. Svenningsen, Thomas Tørring, Thomas B. Poulsen
Published in: Angewandte Chemie International Edition, 2025, Page(s) e202507847, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202507847

Total Synthesis of Natural Products Containing Enamine or Enol Ether Derivatives

Author(s): Thomas B. Poulsen
Published in: Accounts of Chemical Research, Issue 54/8, 2021, Page(s) 1830-1842, ISSN 0001-4842
Publisher: American Chemical Society
DOI: 10.1021/acs.accounts.0c00851

Reactivity-based metabolomics reveal cysteine has glyoxalase 1-like and glyoxalase 2-like activities

Author(s): Marc Daniel Opfermann, Maria Bøgelund Søndergård, Louise Vase Bech, Camilla B. Nielsen, Alejandro Mahía, Charlotte Brinck Holt, Tingting Wang, Sarah Bisgaard Olesen, Kim Frisch, Jakob Appel Østergaard, Dieter Britz, Kirstine Lykke Nielsen, James J. Galligan, Thomas B. Poulsen, Jakob Hansen, Mogens Johannsen
Published in: Nature Chemical Biology, Issue 21, 2025, Page(s) 1397-1407, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-025-01909-0

Expanding the antibacterial selectivity of polyether ionophore antibiotics through diversity-focused semisynthesis

Author(s): Shaoquan Lin, Han Liu, Esben B. Svenningsen, Malene Wollesen, Kristian M. Jacobsen, Frederikke D. Andersen, Jaime Moyano-Villameriel, Christine N. Pedersen, Peter Nørby, Thomas Tørring, Thomas B. Poulsen
Published in: Nature Chemistry, Issue 13/1, 2021, Page(s) 47-55, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-020-00601-1

Total syntheses of cyclohelminthol I–IV reveal a new cysteine-selective covalent reactive group

Author(s): Thomas T. Paulsen, Anders E. Kiib, Gustav J. Wørmer, Stephan M. Hacker, Thomas B. Poulsen
Published in: Chemical Science, Issue 16, 2025, Page(s) 3916-3927, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4sc08667h

α-Lactam Electrophiles for Covalent Chemical Biology

Author(s): Alejandro Mahía, Anders E. Kiib, Marija Nisavic, Esben B. Svenningsen, Johan Palmfeldt, Thomas B. Poulsen
Published in: Angewandte Chemie International edition, 2023, ISSN 1521-3773
Publisher: Wiley-VCH GmbH
DOI: 10.1002/anie.202304142

Other (2)

Modular total synthesis of Lasalocid acid A through direct C(sp3)-C(sp3) attached ring coupling

Author(s): Florian Kromm, Søren Møller, Gustav Wørmer, Adam Jensen, Michelle Rasmussen, Esben Svenningsen, Thomas Tørring, Thomas Poulsen
Published in: 2025
Publisher: ChemRxiv
DOI: 10.26434/chemrxiv-2025-4r44q

Chemoproteomic mapping of the N-terminal cysteinome

Author(s): Esben Svenningsen, Fatih Demir, Florian Kromm, Anna Rahimic, David Olagnier, Markus Rinschen, Thomas Poulsen
Published in: 2024
Publisher: ChemRxiv
DOI: 10.26434/chemrxiv-2024-4w549