Underlying principles in embryonic patterning
Signalling oscillations during embryo segmentation are governed by molecular oscillatory machinery termed a segmentation clock. The segmentation clock is linked to the periodic activity of the Notch, Wnt and Fgf pathway in presomitic mesoderm (PSM) cells. PSM cells display complex, collective synchronisation resulting in wave-like activity patterns sweeping periodically along the embryonic axis. The EU-funded CollectiveDynamics project studies the emergence of collective synchronisation and how the PSM cells decode the relative timing of signalling oscillations. The proposal builds on the discovery that the relative timing between Wnt/Notch oscillations is critical for proper mesoderm patterning. Researchers established an entrainment strategy that enables precise experimental control of oscillation dynamics. Using the medaka fish model, they will entrain and challenge collective synchronisation in vivo to address the integration of signalling oscillations with growth dynamics.
Funding SchemeERC-COG - Consolidator Grant
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