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Collective signaling oscillations in embryonic patterning – revealing underlying principles

Project description

Underlying principles in embryonic patterning

Signalling oscillations during embryo segmentation are governed by molecular oscillatory machinery termed a segmentation clock. The segmentation clock is linked to the periodic activity of the Notch, Wnt and Fgf pathway in presomitic mesoderm (PSM) cells. PSM cells display complex, collective synchronisation resulting in wave-like activity patterns sweeping periodically along the embryonic axis. The EU-funded CollectiveDynamics project studies the emergence of collective synchronisation and how the PSM cells decode the relative timing of signalling oscillations. The proposal builds on the discovery that the relative timing between Wnt/Notch oscillations is critical for proper mesoderm patterning. Researchers established an entrainment strategy that enables precise experimental control of oscillation dynamics. Using the medaka fish model, they will entrain and challenge collective synchronisation in vivo to address the integration of signalling oscillations with growth dynamics.

Call for proposal

ERC-2019-COG
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Host institution

EUROPEAN MOLECULAR BIOLOGY LABORATORY
Address
Meyerhofstrasse 1
69117 Heidelberg
Germany
Activity type
Research Organisations
EU contribution
€ 2 153 310

Beneficiaries (1)

EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 2 153 310
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations