According to the WHO – the antibiotic resistance is one of the biggest threats to global health, food security, and development today. Bacterial species we are continuously studying – the Streptomyces, are the biggest producers of natural antibiotics. So far we are familiar with only a fraction of those. In addition, the Streptomyces have an astounding amount of genes, even half of the number in eukaryotes, most of which are still poorly characterized. Some of those have human counterparts involved in human disease development. The genes we ended up studying in more depth are a pair of one from Streptomyces bacterial species and its viral SARS-Cov2 homologue. They are in their function different, but similar in their structure, and very likely, in the way (the mechanism) of how they function and can be inhibited. So, the knowledge on the structure and the mechanism of action/inhibition we found, when integrated, give us insight into how new inhibitors for bacterial toxins and essential viral proteins can be designed. The same pipeline can be used in the future on any similar protein contained in any new pathogen – both in the bacteria and viruses.