Objective
Worldwide, human papillomaviruses (HPV) are responsible for approximately half a million new cervical cancer cases every year and more than 200.000 deaths. More than a half of these cases is caused by HPV type 16. The vaccine research was hindered with the extremely low number of particles found in clinical samples and with the impossibility to cultivate the virus in vitro. During early 90s with the onset of molecular biology techniques the balance began to change. First generation preventive vaccines against HPVs are entering clinical trials recently. These vaccines are mostly based on recombinant HPV virus like particles (VLP) containing major capsid protein L1 expressed in yeast, insect or mammalian cell cultures. Early results from the clinical trial s show, that HPV infection and so the majority of cervical cancer cases can be prevented with VLP based vaccine.
However the cost of vaccine and its distribution can limit it's use, particularly in developing countries, where it is most needed. In this pro ject we want to take advantage of novel system for expression and accumulation of pharmaceutically valuable proteins in protein bodies in soybean seed to express HPV virus like particles. This will offer safe and inexpensive alternative to current expression systems. The goal is also to reach sufficient levels of papillomavirus VLP for oral vaccination to further lower the vaccination cost. The low water content, sub-cellular compartmentalization and natural trypsin inhibitor content should offer additional benefit of prolonged stability of the expressed protein. Another benefit of the project is extensive multidisciplinary training for the applicant. As a part of the project the Danforth Plant Science Centre will provide training in unique set of techniques: Glycine max transformation, tissue and compartment specific protein expression, microscopy techniques, structural biology and immunology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine immunology immunisation
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences clinical medicine oncology cervical cancer
- medical and health sciences health sciences infectious diseases DNA viruses
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-6
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
PRAGUE
Czechia
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.