Objective
Glycine and GABA are the two major fast inhibitory neurotransmitters of the mammalian central nervous system. The necessity for two fast inhibitory systems is a long-standing question and the functional responsibilities of each transmitter systems are not yet known. GABA and glycine act at distinct ionotropic receptors and are released by separated neurons or co-released by mixed inhibitory neurons. Although glycinergic and GABAergic receptors share structural and biophysical similarities, GABA transmission cannot compensate for a disruption in glycine transmission, for example mutations of the glycine receptors results in a severe human channelopathy that is characterized by hyperekplexia . GABAergic and glycinergic neurons share the same vesicular transporter (VIAAT) for packaging GABA and/or glycine into synaptic vesicles.
Therefore, the vesicular content in inhibitory amino acids should be solely dependent on their relative cytoplasmic concentrations. The plasma membrane transporter GLYT2 is a neuron specific plasma membrane transporter of glycine that can maintain a million fold glycine gradients across the neuronal membrane. We will use in vitro and in vivo electrophysiological and immunocytochemical techniques in to investigate the hypothesis that the expression of GLYT2 on the presynaptic neuron is the only prerequisite for an inhibitory neuron (i.e. expressing VIAAT) to store and release glycine. During brain development, some GABAergic interneurons switch their phenotype to releasing glycine.
This suggests glycine may be specifically required at some developmental time points due to an additional functional capability. We will investigate the role of GLYT2 in this GABA to glycine switch and assess the role this switch plays in developing brain networks. The successful completion of this project will be of benefit to both the candidate and the host institute, as well as to the Europeans research community as a whole.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics mutation
- natural sciences chemical sciences organic chemistry amines
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.