Innovative cancer therapy through Myc inhibition: taking OMO-103 to market

Project Information

MYCure

Grant agreement ID: 872212

DOI 10.3030/872212

Project closed

EC signature date 28 August 2019

Start date 1 June 2019

End date 31 December 2022

Funded under

• INDUSTRIAL LEADERSHIP - Innovation In SMEs

Total cost € 6 222 158,75

EU contribution € 2 219 553,52

Coordinated by

PEPTOMYC SL
Spain

Deliverables

Websites, patent fillings, videos etc. (1)

MYCure Dissemination materials & website

Website of the project and dissemination materials.

Publications

Peer reviewed articles (15)

Frequent mutations of FBXO11 highlight BCL6 as a therapeutic target in Burkitt lymphoma.

Author(s): Chiara Pighi, Taek-Chin Cheong, Mara Compagno, Enrico Patrucco, Maddalena Arigoni, Martina Olivero, Qi Wang, Cristina López, Stephan H. Bernhart, Bruno M. Grande, Teresa Poggio, Fernanda Langellotto, Lisa Bonello, Riccardo Dall’Olio, Sandra Martínez-Martín, Luca Molinaro, Paola Francia di Celle, Jonathan R. Whitfield, Laura Soucek, Claudia Voena, Raffaele Calogero, Ryan D. Morin, Louis M. Sta
Published in: Blood Advances 2021, Issue (2021) 5 (23), 2021, Page(s) 5239–5257, ISSN 2473-9537
Publisher: ASH Publications
DOI: 10.1182/bloodadvances.2021005682

The long journey to bring a Myc inhibitor to the clinic

Author(s): Jonathan R. Whitfield, Laura Soucek
Published in: Journal of Cell Biology, Issue 220/8, 2021, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202103090

MYC inhibitors in multiple myeloma

Author(s): Martínez-Martín S, Soucek L.
Published in: Cancer Drug Resistance, Issue Aug 13;4(4):, 2021, Page(s) 842-865, ISSN 2578-532X
Publisher: OAE Publishing Inc.
DOI: 10.20517/cdr.2021.55.

Integrated requirement of non‐specific and sequence‐specific DNA binding in Myc‐driven transcription

Author(s): Paola Pellanda, Mattia Dalsass, Marco Filipuzzi, Alessia Loffreda, Alessandro Verrecchia, Virginia Castillo Cano, Hugo Thabussot, Mirko Doni, Marco J Morelli, Laura Soucek, Theresia Kress, Davide Mazza, Marina Mapelli, Marie‐Eve Beaulieu, Bruno Amati, Arianna Sabò
Published in: The EMBO Journal, Issue 40/10, 2021, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2020105464

The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets

Author(s): Mariano F. Zacarías-Fluck, Toni Jauset, Sandra Martínez-Martín, Jastrinjan Kaur, Sílvia Casacuberta-Serra, Daniel Massó-Vallés, Erika Serrano del Pozo, Génesis Martín-Fernández, Íñigo González-Larreategui, Sergio López-Estévez, Lamorna Brown-Swigart, Marie-Eve Beaulieu, Jonathan R. Whitfield, Babita Madan, David M. Virshu4, Gerard I. Evan and Laura Soucek.
Published in: Life Sci Alliance., Issue Volume 4, No. 5; 02/03/2021, 2021, ISSN 2575-1077
Publisher: Life Sci Alliance.

MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding.

Author(s): Daniel Massó-Vallés, Marie-Eve Beaulieu, Toni Jauset, Fabio Giuntini, Mariano F. Zacarías-Fluck, Laia Foradada, Sandra Martínez-Martín, Erika Serrano, Génesis Martín-Fernández, Sílvia Casacuberta-Serra, Virginia Castillo Cano, Jastrinjan Kaur, Sergio López-Estévez, Miguel Ángel Morcillo, Mohammad Alzrigat, Loay Mahmoud, Antonio Luque-García, Marta Escorihuela, Marta Guzman, Joaquín A
Published in: Cancer Research Communications, Issue (2022) 2 (2), 2022, Page(s) 110–130, ISSN 2767-9764
Publisher: AACR
DOI: 10.1158/2767-9764

A spotlight on cancer researchers in Spain: new paradigms and disruptive ideas

Author(s): S. Ramón y Cajal, P. Sancho, L. Soucek, H. Peinado, M. Abad, M. Valiente, A. Efeyan, J. Pardo, V. Quesada, J. Jimeno, P. M. Duque, A. Antón, I. Varela, A. J. Schuhmacher
Published in: Clinical and Translational Oncology, Issue 22/6, 2020, Page(s) 798-801, ISSN 1699-048X
Publisher: Doyma
DOI: 10.1007/s12094-019-02199-4

Editorial overview: Peptides in cancer

Author(s): Jonathan Whitfield, Laura Soucek
Published in: Current Opinion in Pharmacology, Issue 47, 2019, Page(s) iii-v, ISSN 1471-4892
Publisher: Elsevier BV
DOI: 10.1016/j.coph.2019.06.001

Finding MYCure

Author(s): Marie-Eve Beaulieu, Laura Soucek
Published in: Molecular & Cellular Oncology, Issue 6/5, 2019, Page(s) e1618178, ISSN 2372-3556
Publisher: Taylor & Francis Online
DOI: 10.1080/23723556.2019.1618178

MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype

Author(s): Nicole M. Sodir, Roderik M. Kortlever, Valentin J.A. Barthet, Tania Campos, Luca Pellegrinet, Steven Kupczak, Panayiotis Anastasiou, Lamorna Brown Swigart, Laura Soucek, Mark J. Arends, Trevor D. Littlewood, Gerard I. Evan
Published in: Cancer Discovery, Issue 10/4, 2020, Page(s) 588-607, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-19-0435

Blocking Myc to Treat Cancer: Reflecting on Two Decades of Omomyc

Author(s): Daniel Massó-Vallés, Laura Soucek
Published in: Cells, Issue 9/4, 2020, Page(s) 883, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9040883

Structural and Biophysical Insights into the Function of the Intrinsically Disordered Myc Oncoprotein

Author(s): Marie-Eve Beaulieu, Francisco Castillo, Laura Soucek
Published in: Cells, Issue 9/4, 2020, Page(s) 1038, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9041038

Targeting Antitumoral Proteins to Breast Cancer by Local Administration of Functional Inclusion Bodies

Author(s): Mireia Pesarrodona, Toni Jauset, Zamira V. Díaz‐Riascos, Alejandro Sánchez‐Chardi, Marie‐Eve Beaulieu, Joaquin Seras‐Franzoso, Laura Sánchez‐García, Ricardo Baltà‐Foix, Sandra Mancilla, Yolanda Fernández, Ursula Rinas, Simó Schwartz, Laura Soucek, Antonio Villaverde, Ibane Abasolo, Esther Vázquez
Published in: Advanced Science, Issue 6/18, 2019, Page(s) 1900849, ISSN 2198-3844
Publisher: Wiley-VCH
DOI: 10.1002/advs.201900849

Pharmacokinetic analysis of Omomyc shows lasting structural integrity and long terminal half-life in tumor tissue.

Author(s): Marie-Eve Beaulieu, Sandra Martínez-Martín, Jastrinjan Kaur, Virginia Castillo Cano, Daniel Massó-Vallés, Laia Foradada Felip, Sergio López-Estévez, Erika Serrano del Pozo, Hugo Thabussot and Laura Soucek.
Published in: Cancers. 2023, Issue 2023 Jan 29;15(3), 2023, Page(s) 826, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15030826 

Going for a “KDIP” in colorectal cancer treatment.

Author(s): Jastrinjan Kaur and Laura Soucek.
Published in: Clinical and Translational Discovery 2022, Issue (2022) 7 (17), 2022, Page(s) e108, ISSN 2768-0622
Publisher: Wiley Online Library
DOI: 10.1002/ctd2.108

Conference proceedings (1)

Abstract 1225: Aberrant SMAD3 signaling in tumor-associated fibroblasts modulates fibrosis and response to the anti-fibrotic drug nintedanib in non-small cell lung cancer

Author(s): Rafael Ikemori, Marta Gabasa, Miguel Vizoso, Paula Duch, Sebastian Moran, Sabrina Gea-Sorli, Paloma Bragado, Toni Jauset, Manel Esteller, Laura Soucek, Eduard Monsó, Víctor Peinado, Cristina Fillat, Frank Hilberg, Noemí Reguart, Jordi Alcaraz
Published in: Experimental and Molecular Therapeutics, 2019, Page(s) 1225-1225
Publisher: American Association for Cancer Research
DOI: 10.1158/1538-7445.am2019-1225

Intellectual Property Rights

Other (1)

METHOD FOR PREDICTING RESPONSE TO A CANCER TREATMENT

Application/Publication number: EP22383031.6 EP22383031.6
Date: 2022-10-28
Applicant(s): PEPTOMYC SL