Objective
Most medically and agronomically important traits are ¿multifactorial¿ phenotypes influenced by multiple polygenes or Quantitative Trait Loci (QTL) as well as environmental factors. Identifying the genes influencing such ¿complex¿ traits is one of the most important goals of modern genetics, as it paves the way towards numerous important medical and agricultural applications.
One of the most important bottlenecks towards that goal is the difficulty to accurately determine the location of QTL on the genome, i.e. the difficulties to fine-map QTL with an accuracy that is sufficient to allow for the identification of the causal genes and mutations. We herein propose to apply a novel strategy to fine-map a QTL influencing female fertility in dairy cattle that was previously identified by the host laboratory. Improving female fertility is becoming an important component in present day selection objectives targeting health and well fare more than only production efficacy per se.
The proposed strategy has three major features:
(i) computer aided development of high density maker maps in the chromosome regions of interest,
(ii) the exploitation of linkage disequilibrium as a means to increase the cross-over density in the chromosome region of interest,
(iii) increasing QTL "detectance" by means of progeny-testing and marker assisted segregation analysis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences biological sciences genetics DNA
- medical and health sciences medical biotechnology genetic engineering
- natural sciences biological sciences genetics mutation
- medical and health sciences basic medicine physiology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
LIEGE (SART TILMAN)
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.