Insight into host–microbe dialogue
The interplay between the immune system and the gut microbiota is paramount for tissue health and shapes immune responses against pathogens. Changes in gut microbiota have been documented to perturb immune function and lead to several inflammatory gut disorders. The EU-funded BIF-PROTECTS project is focussing on Bifidobacteria, a Gram-positive commensal species currently under investigation in many clinical trials for its health-promoting effects (probiotics). Scientists will investigate the anti-inflammatory mechanisms of Bifidobacterium breve and replicate their effect using a synthetic biology approach. Collectively, the project's results will help delineate the host–microbe dialogue and contribute to the development of novel microbiome-based immunotherapy treatments.
Fields of science
Call for proposal
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