Project description
Probing protein structure and dynamics at the nanoscale
First presented in 2012, single-molecule metal-induced energy transfer can be used to determine the position of individual molecules near a metal surface with nanometre accuracy. When a fluorescent molecule is brought close to a metal surface, it transfers its excited state energy to surface plasmons in the metal. Researchers have been using this method for mapping cellular membranes with nanometre axial resolution. The aim of the EU-funded smMIET project is to expand the potential applications of this novel single-molecule localisation concept. In particular, the project will apply the technology for resolving the global structure of macromolecular complexes, the conformational fluctuations of intrinsically disordered proteins, the dynamics of lipid membranes, or the transport of proteins across lipid bilayers.
Fields of science
- natural sciencesphysical sciencesopticsspectroscopy
- natural sciencesphysical sciencesopticsmicroscopyfluorescence lifetime imaging
- natural sciencesbiological sciencesbiochemistrybiomoleculeslipids
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- natural sciencesphysical sciencesopticsmicroscopysuper resolution microscopy
Topic(s)
Call for proposal
ERC-2019-ADG
See other projects for this call
Funding Scheme
ERC-ADG - Advanced GrantHost institution
37073 Gottingen
Germany
Beneficiaries (1)
37073 Gottingen