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Single-Molecule Metal-Induced Energy Transfer (smMIET)

Project description

Probing protein structure and dynamics at the nanoscale

First presented in 2012, single-molecule metal-induced energy transfer can be used to determine the position of individual molecules near a metal surface with nanometre accuracy. When a fluorescent molecule is brought close to a metal surface, it transfers its excited state energy to surface plasmons in the metal. Researchers have been using this method for mapping cellular membranes with nanometre axial resolution. The aim of the EU-funded smMIET project is to expand the potential applications of this novel single-molecule localisation concept. In particular, the project will apply the technology for resolving the global structure of macromolecular complexes, the conformational fluctuations of intrinsically disordered proteins, the dynamics of lipid membranes, or the transport of proteins across lipid bilayers.

Call for proposal

ERC-2019-ADG
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Host institution

GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS
Address
Wilhelmsplatz 1
37073 Gottingen
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 740 188

Beneficiaries (1)

GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS
Germany
EU contribution
€ 2 740 188
Address
Wilhelmsplatz 1
37073 Gottingen
Activity type
Higher or Secondary Education Establishments