Let there be light to reveal brain circuits with the resolution of single cells
Decades of research building on advances in experimental methods, technologies and theoretical models harnessing the power of computing have all made tremendous contributions to our understanding of the brain's structure and function. As the saying goes, the more we know, the more we realise how much we do not yet know. The ultimate goal is to understand how the activity of individual neurons in separate brain regions comes together to subserve whole-brain functions, much as the individual notes of different instruments contribute to a symphony. However, given the approximately 80 billion neurons in the human brain, reaching this goal remains elusive. The EU-funded HOLOVIS project is developing high-tech optical technologies to reveal mid-scale circuit connectivity and ensemble function with single-cell resolution.
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