Engineering Carbon Nanodots for (Nano)Technological and Biomedical Applications

Project Information

e-DOTS

Grant agreement ID: 885323

DOI

10.3030/885323

Project closed

EC signature date 7 September 2020

Start date 1 January 2021

End date 30 June 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (30)

Covalent functionalisation controlled by molecular design for the aptameric recognition of serotonin in graphene-based field-effect transistors

Author(s): Wetzl, C; Brosel-Oliu, S; Carini, M; Di Silvio, D; Illa, X; Villa, R; Guimerà Brunet, A; Prats-Alfonso, E; Prato, M; Criado, A.
Published in: Nanoscale, Issue 15, 2023, Page(s) 16650-16657, ISSN 2040-3372
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3nr04153k

Temperature-Dependent Luminescence of Nd³⁺-Doped Carbon Nanodots for Nanothermometry

Author(s): Cecilia Wetzl, Carlos Renero-Lecuna, Lucia Cardo, Luis M. Liz-Marzán, Maurizio Prato
Published in: ACS Applied Materials & Interfaces, Issue 16, 2024, Page(s) 35484-35493, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.4c07605

The Importance of the Purification Step and the Characterization of the Products in the Synthesis of Carbon Nanodots

Author(s): Bartolomei, B; Prato, M.
Published in: Small, 2023, ISSN 1613-6829
Publisher: Wiley-VCH GmbH
DOI: 10.1002/smll.202206714

Carbon-dots conductometric sensor for high performance gas sensing

Author(s): Article S. Sawalha; K. Moulae; G. Nocito; A. Silvestri; S. Petralia; M. Prato; S. Bettini; L. Valli; S. Conoci; G. Neri
Published in: Carbon Trends, Issue 5, 2021, ISSN 2667-0569
Publisher: Elsevier
DOI: 10.1016/j.cartre.2021.100105

Chiral Carbon Nanodots Can Act as Molecular Catalysts in Chemical and Photochemical Reactions

Author(s): Bartolomei, B; Corti, V; Prato, M.
Published in: Angewandte Chemie International Edition, 2023, ISSN 1521-3773
Publisher: Wiley
DOI: 10.1002/anie.202305460

Shining Light on Carbon Dots: New Opportunities in Photocatalysis

Author(s): Sbacchi, M; Mamone, M; Morbiato, L; Gobbo, P; Filippini, G; Prato, M.
Published in: ChemCatChem, 2023, ISSN 1867-3899
Publisher: Wiley-VCH GmbH
DOI: 10.1002/cctc.202300667

Carbon dots conjugated to SN38 for improved colorectal anticancer therapy

Author(s): Article Mattinzoli, D; Cacioppo, M; Ikehata, M; Armelloni, S; Al, CM; Castellano, G; Barilani, M; Arcudi, F; Messa, P; Prato, M
Published in: Materials Today Bio, Issue 16, 2022, ISSN 2590-0064
Publisher: Elsevier
DOI: 10.1016/j.mtbio.2022.100286

Broad-Spectrum Antibacterial Activity of Synthesized Carbon Nanodots from D-Glucose

Author(s): Sawalha, S; Assali, M; Raddad, M; Ghneem, T; Sawalhi, T; Almasri, M; Zarour, A; Misia, G; Prato, M; Silvestri A.
Published in: ACS Applied Bio Materials, Issue 5,10, 2022, Page(s) 4860-4872, ISSN 2576-6422
Publisher: ACS publications
DOI: 10.1021/acsabm.2c00590

Carbon dots as multi-modal contrast agents: opportunities and open challenges for in vivo bioimaging

Author(s): Elisa Sturabotti, Beatriz Sierra-Serrano, Samantha Marcelino Apresto, Michele Cesco, Luca Comparini, Lucia Cardo, Maurizio Prato
Published in: Advanced Drug Delivery Reviews, Issue 224, 2026, Page(s) 115659, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2025.115659

A multifunctional chemical toolbox to engineer carbon dots for biomedical and energy applications

Author(s): Ðordevic, L; Arcudi, F; Cacioppo, M; Prato, M.
Published in: Nature Nanotechnology, Issue 17-2, 2022, Page(s) 112-130, ISSN 1748-3387
Publisher: Nature Publishing Group
DOI: 10.1038/s41565-021-01051-7

Going Deep into the Surface Chemistry of Carbon Dots: Influence of Functional Groups on the Redox Abilities

Author(s): Laura Morbiato, Maria Sbacchi, Jacopo Dosso, Paolo Pengo, Pierangelo Gobbo, Giacomo Filippini, Maurizio Prato
Published in: Small, Issue 22, 2026, Page(s) e14420, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202514420

Impact of Proteins on the Cellular Uptake of Carbon Nanodots

Author(s): Ziyao Liu, Huijie Yan, I. Jénnifer Gómez, Carolina Carrillo Carion, Blanca Arnaiz, Dingcheng Zhu, Maurizio Prato, Wolfgang J. Parak, Neus Feliu, Michele Cacioppo
Published in: ACS Omega, Issue 10, 2025, Page(s) 60928-60935, ISSN 2470-1343
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acsomega.5c09510

Molecular Insights into the Formation and Functionalization of Carbon Nanodots: From Precursor Intermediates to Surface Chemistry Quantification

Author(s): Emanuele Giuliani, Maria Sbacchi, Serena Agostini, Giacomo Filippini, Beatrice Bartolomei, Pierangelo Gobbo, Maurizio Prato
Published in: Angewandte Chemie, Issue 137, 2026, Page(s) e202515073, ISSN 0044-8249
Publisher: Wiley
DOI: 10.1002/ange.202515073

Luminescent Carbon Nanodots Doped with Gadolinium (III): Purification Criteria, Chemical and Biological Characterization of a New Dual Fluorescence/MR Imaging Agent

Author(s): Cardo, L; Martínez-Parra, L; Cesco, M; Echeverría-Beistegui, BM; Martínez-Moro, M; Herrero-Álvarez, N; Cabrerizo, M; Carregal-Romero, S; Ramos-Cabrer, P; Ruiz-Cabello, J; Prato, M.
Published in: Small, 2023, Page(s) 2206442, ISSN 1613-6829
Publisher: Wiley
DOI: 10.1002/smll.202206442

Influence of the chirality of carbon nanodots on their interaction with proteins and cells

Author(s): Yan, HJ; Cacioppo, M; Megahed, S; Arcudi, F; Dordevic, L; Zhu, DC; Schulz, F; Prato, M; Parak, WJ; Feliu, N
Published in: Nature Communications, Issue 12-1, 2021, Page(s) 7208, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-27406-1

Synthetic Strategies for the Selective Functionalization of Carbon Nanodots Allow Optically Communicating Suprastructures

Author(s): Bartolomei, B.; Sbacchi, M.; Rosso, C.; Gunay-Gurer, A.; Zdrazil, L.; Cadranel, A.; Kralj, S.; Guldi, D.; Prato, M.
Published in: Angewandte Chemie International Edition, 2023, Page(s) e202316915, ISSN 1521-3773
Publisher: Wiley
DOI: 10.1002/anie.202316915

Carbon dots for drug delivery: Insights into their potential in nanopharmacology

Author(s): Daniela Iannazzo, Consuelo Celesti, Lucia Cardo, Maurizio Prato, Alessandra Bitto
Published in: Pharmacological Reviews, Issue 78, 2026, Page(s) 100107, ISSN 0031-6997
Publisher: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1016/j.pharmr.2025.100107

Microwave-assisted one-step synthesis of water-soluble manganese-carbon nanodot clusters

Author(s): Gomez-Blanco, N; Prato, M.
Published in: Communications Chemistry, Issue 6-1, 2023, ISSN 2399-3669
Publisher: Nature Research
DOI: 10.1038/s42004-023-00983-6

Phenol‐Rich Carbon Dots as Metal‐Free Nano‐Photocatalysts for [3 + 2] Cycloaddition Reactions

Author(s): Martina Mamone, Giuseppe Gentile, Maurizio Prato, Giacomo Filippini
Published in: ChemSusChem, Issue 18, 2025, Page(s) e202500521, ISSN 1864-5631
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.202500521

Lighting up the Electrochemiluminescence of Carbon Dots through Pre- and Post-Synthetic Design

Author(s): Arcudi, F; Ðorđević, L; Rebeccani, S; Cacioppo, M; Zanut, A; Valenti, G; Paolucci, F; Prato, M.
Published in: Advanced Science, Issue 8 - 13, 2021, Page(s) 2100125, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202100125

Fe-doped carbon dots as dual-mode <i>T</i> ₁ / <i>T</i> ₂ nano-contrast agents for ultra-high field MRI

Author(s): Beatriz Sierra-Serrano, Elisa Sturabotti, Lucia Cardo, Maurizio Prato
Published in: Nanoscale, Issue 18, 2026, Page(s) 7501-7515, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d5nr04400f

Multifunctional graphene quantum dots: A therapeutic strategy for neurodegenerative diseases by regulating calcium influx, crossing the blood-brain barrier and inhibiting Aβ-protein aggregation

Author(s): I. Jénnifer Gómez, Petra Křížková, Anna Dolečková, Lucía Cardo, Cecilia Wetzl, Naděžda Pizúrová, Maurizio Prato, Jiřina Medalová, Lenka Zajíčková
Published in: Applied Materials Today, Issue 36, 2024, Page(s) 102072, ISSN 2352-9407
Publisher: Elsevier BV
DOI: 10.1016/j.apmt.2024.102072

Tailoring the Chemical Structure of Nitrogen-Doped Carbon Dots for Nano-Aminocatalysis in Aqueous Media

Author(s): Gentile, G; Mamone, M; Rosso, C; Amato, F; Lanfrit, C; Filippini, G; Prato, M
Published in: ChemSusChem, 2023, ISSN 1864-564X
Publisher: Wiley
DOI: 10.1002/cssc.202202399

Snapshots into carbon dots formation through a combined spectroscopic approach

Author(s): Rigodanza, F; Burian, M; Arcudi, F; Đorđević, L; Amenitsch, H; Prato, M.
Published in: Nature Communications, Issue 12-1, 2021, Page(s) 2640, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-22902-w

Transfer of Axial Chirality to the Nanoscale Endows Carbon Nanodots with Circularly Polarized Luminescence

Author(s): Prato, M; Di Noja, S; Amato, F; Zinna, F; Di Bari, L; Ragazzon, G.
Published in: Angewandte Chemie International Edition, 2022, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202202397

Nuclear Magnetic Resonance Reveals Molecular Species in Carbon Nanodot Samples Disclosing Flaws

Author(s): Prato, M; Bartolomei, B; Bogo, A; Amato, F; Ragazzon, G.
Published in: Angewandte Chemie International Edition, 2022, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202200038

Water Permeates and Plasticizes Amorphous Carbon Dots: Unraveling the Inner Accessibility of the Nanoparticles by Glass Transition Studies

Author(s): Elisa Sturabotti, Valerio Di Lisio, Lucia Cardo, Alessandro Camilli, Estela Moretón Alfonsín, Daniele Cangialosi, Amaia Iturrospe Ibarra, Arantxa Arbe, Maurizio Prato
Published in: Advanced Materials, 2025, Page(s) e10992, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202510992

Nitrogen-Rich Carbon Dots as Effective Catalysts in the 1,4-Reduction of α,β-Unsaturated Aldehydes via Ion Pair Asymmetric Nano-Organocatalysis

Author(s): Alessio Carioscia, Emanuele Cocco, Maria Edith Casacchia, Giuseppe Gentile, Martina Mamone, Giuliana Giorgianni, Elena Incerto, Maurizio Prato, Fabio Pesciaioli, Giacomo Filippini, Armando Carlone
Published in: ACS Catalysis, Issue 14, 2024, Page(s) 13429-13438, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.4c03532

Structure Matters: Tailored Graphitization of Carbon Dots Enhances Photocatalytic Performance

Author(s): Laura Morbiato, Lucia Cardo, Elisa Sturabotti, Pierangelo Gobbo, Giacomo Filippini, Maurizio Prato
Published in: ACS Nano, Issue 19, 2025, Page(s) 4887-4900, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.4c16538

Amine-Rich Carbon Dots as Novel Nano-Aminocatalytic Platforms in Organic Synthesis

Author(s): Article Corti, V; Bartolomei, B; Mamone, M; Gentile, G; Prato, M; Filippini, G
Published in: European Journal of Organic Chemistry, Issue 41, 2022, ISSN 1099-0690
Publisher: Wiley-VCH GmbH
DOI: 10.1002/ejoc.202200879