Periodic Reporting for period 1 - NORATEST (NORATEST: An e-Health solution for a better Alzheimer's diagnosis and management) Reporting period: 2019-12-01 to 2020-03-31 Summary of the context and overall objectives of the project Alzheimer’s disease (AD) is one of the most common diseases in the ageing population, ranking as the fifth leading cause of death. It affects more than 50 Million people worldwide and generates annual expenses near to €1 Trillion in total caring costs. Current tools to diagnose AD are expensive, inaccurate, invasive and in most cases, they are able to detect the disease only at advanced stages, which reduce the chances of treatment. With NoraTest, ALZOHIS will provide a timely and cost-effective method for AD diagnosis, which will allow the detection of symptoms earlier than the current methods, thus reducing the impact and cost of AD on society. NoraTest is based in a simple blood test analysis coupled to an analytical algorithm which provides an accurate score regarding the possibility of having AD. The goal of this feasibility study was to assess the viability of NoraTest from a technical, regulatory, commercial and financial perspective. Our study shows that NoraTest is a solid project that will generate important benefits for our company. By 2025, ALZOHIS expects cumulative gross profits of over €28 Million, with a payback period of less than 4 years. Work performed from the beginning of the project to the end of the period covered by the report and main results achieved so far During Phase 1 of NoraTest project we analyzed the technical features of our product and determined which improvements are needed to obtain a highly accurate and predictive algorithm for the diagnostic of Alzheimer’s disease. Moreover, we designed a development plan complying with all regulatory policies for the commercialization of NoraTest in the EU and US. We carefully analyzed the market with its trends and barriers. We developed a detailed exploitation and dissemination plan and a strong IPR strategy to protect our invention. Finally, we performed a financial analysis demonstrating that NoraTest project is profitable with an expected 5-years ROI of 1.73. Progress beyond the state of the art and expected potential impact (including the socio-economic impact and the wider societal implications of the project so far) With an additional investment of €2.9 Million, we will be able to complete NoraTest project for international commercialization. We expect to launch NoraTest in France by Q4 2020 and then expand to the rest of Europe and the US. We expect a total revenue of €18.2 Million by 2025, while generating 10 new job positions. Besides, by introducing NoraTest onto the market, we will provide an accurate tool for early detection of Alzheimer’s disease which will positively impact patients, families, the healthcare system and even neurobiology research.