Project description
A new gene implicated in magnesium homeostasis
Disturbances in magnesium homeostasis such as hypomagnesemia are associated with various metabolic disorders and could be caused by impaired magnesium transport. Magnesium homeostasis is regulated by the kidney through complex processes of excretion and reabsorption. To elucidate the mechanisms underlying hypomagnesemia, the EU-funded OMG project will decipher the mechanism of action of the newly discovered magnesiotropic gene OIT3. Through a variety of different approaches, scientists will unveil the role of OIT3 in magnesium homeostasis and in human kidney disease. This could lead to the discovery of potential therapeutic targets and biomarkers of electrolyte-related kidney disease.
Objective
Mg2+ is the second most abundant intracellular cation after potassium and it plays an essential role in the human body. The kidney is the key organ regulating Mg2+ homeostasis through complex processes of excretion and reabsorption. This takes place in the nephrons, the functional units of the kidney, via paracellular mechanisms and ion transporters. Alterations in Mg2+ homeostasis are associated with several diseases and vice versa. Hypomagnesemia (serum Mg2+ <0.70 mmol/L) is the most common form of Mg2+ disturbance which can be due to impaired intestinal Mg2+ absorption or renal Mg2+ wasting. Remarkably, hypomagnesemia is associated with highly prevalent metabolic disorders including diabetes and metabolic syndrome. In the past, many genetic causes of hypomagnesemia and renal Mg2+ wasting have been identified in humans, encompassing mutations in magnesiotropic genes. This has been crucial to decipher part of the mechanisms involved in Mg2+ transport and renal (patho)physiology. However, many cases of Mg2+ disturbances cannot be explained with the current knowledge, meaning that there is a clinical need to further elucidate the mechanisms underlying hypomagnesemia to find an effective treatment. Recently, we have discovered OIT3, a new gene involved in Mg2+ handling. However, the mechanisms of action and its physiological role need to be deciphered. The aim of the present project is to unravel the physiological role and mechanisms of action of OIT3 in relation to Mg2+ handling as well as find clinical indications from human kidney disease where OIT3 can play a role. Applying a wide range of techniques including electrolyte analysis, advanced microscopy, RNAseq and bioinformatics, I will provide mechanistic insights and a holistic view into the role of OIT3 in renal Mg2+ homeostasis. This approach will contribute to the discovery of potential therapeutic targets and biomarkers of electrolyte-related kidney disease.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry alkali metals
- medical and health sciences clinical medicine endocrinology diabetes
- natural sciences biological sciences genetics mutation
- medical and health sciences basic medicine physiology homeostasis
- medical and health sciences clinical medicine nephrology kidney diseases
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2019
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
6525 GA NIJMEGEN
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.