Objective
Molecular scale interactions at artificial and naturally occurring responsive surfaces, e.g. the cell membrane, play a crucial role in many biological and biomedical processes. Responsive surfaces with molecular level control are considered as key to many crucial problems in nanobiotechnology. We aim at contributing to the development of such surfaces starting from a fundamental understanding of structure-property relationships in advanced nanomaterials and processes from the molecular scale. Specifically we propose to investigate the translation of external stimuli into forces in single macromolecules by means of atomic force microscopy (AFM) measurements for two classes of stimuli-responsive polymers, i.e. unique redox-active organometallic poly (ferrocenyl silanes) and elastin-based biopolymers.
The communication with single molecules occurs via conformational/dimensional changes of these polymers under stress via changes in chain torsional potential energy landscape and thus variations in the corresponding macromolecular characteristic ratio. These occur upon redox stimulation or upon changes in e.g. temperature or pH. The challenging project will be tackled in a rational manner (control instead of trial and error) by depositing molecules individually at precisely defined positions using scanning probe lithography. Subsequently, the nanomechanical properties of an ensemble of individually addressable molecules will be probed molecule for molecule by single molecule force spectroscopy, hence avoiding a convolution of data of many molecules.
This approach will also be utilized to selectively pick up individual macromolecules by chemically functionalised tips, followed by AFM measurements that aim at unravelling the effects of several external stimuli on the macromolecules response. Based on the results, responsive surfaces with molecular level control can be designed for applications in the areas of (bio) sensors, drug delivery, nano/ microfluidics, and smart coatings.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences classical mechanics fluid mechanics microfluidics
- natural sciences chemical sciences polymer sciences
- natural sciences physical sciences optics microscopy
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- natural sciences physical sciences optics spectroscopy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
ENSCHEDE
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.