Crosstalk between macrophages and cancer cells
Macrophages are key immune cells responsible for digesting foreign substances, pathogens and cancer cells. Understanding how these cells migrate within tumours in response to extracellular cues is paramount for harnessing their immunotherapeutic power. To address this, the EU-funded CHECKMATE project will investigate the influence of chemical and mechanical signals on macrophage migration. Scientists will employ 3D scaffolds and tumour aggregates to monitor macrophage migration following stimulation with different growth factors and chemokines. They will also apply mechanical stress and try to recapitulate variable oxygen and glucose conditions. The results will help paint a more detailed picture of macrophage activation, migration and function in cancer.