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Alteration of Mfn2 protein and Endoplasmic Reticulum to Mitochondria calciUm transfer in STress

Project description

The role of stress on specialised cellular hubs

Stress threatens the organism's homeostasis inducing changes in metabolic demands from the brain, while in chronic conditions it can lead to behavioural changes and even psychopathologies. The EU-funded aMUST project aims to investigate the mechanisms implicated in stress responses, focussing on the role of mitochondrial–endoplasmic reticulum (ER) associated membranes (MAMs). Using endoscopic methods, scientists will study mitochondrial dynamics in stress-vulnerable brain regions and determine MAM composition in response to stress. They will also explore various strategies to alleviate stress-induced alterations, opening the possibility for the development of novel therapies against stress-related conditions, including anxiety and depression.

Coordinator

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Net EU contribution
€ 191 149,44
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Switzerland

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Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00