Project description
The role of stress on specialised cellular hubs
Stress threatens the organism's homeostasis inducing changes in metabolic demands from the brain, while in chronic conditions it can lead to behavioural changes and even psychopathologies. The EU-funded aMUST project aims to investigate the mechanisms implicated in stress responses, focussing on the role of mitochondrial–endoplasmic reticulum (ER) associated membranes (MAMs). Using endoscopic methods, scientists will study mitochondrial dynamics in stress-vulnerable brain regions and determine MAM composition in response to stress. They will also explore various strategies to alleviate stress-induced alterations, opening the possibility for the development of novel therapies against stress-related conditions, including anxiety and depression.
Objective
Stress conditions threaten the organism’s homeostasis triggering adaptative responses. One of them is the increased energy demand from the brain. When stress becomes chronic, it leads to behavioural changes that range from adaptation to psychopathology. aMUST project aims to understand the neurobiological mechanisms underlying stress response. Considering that nowadays chronic stress is a risk factor for psychopathologies, such as anxiety and depression, with 25% of incidence in the population and an economical burden of €170 billion/year in EU, the aMUST project is extremely relevant and timely. Mitochondria and bioenergetics are emerging as important key players in stress-related pathologies. Whereas the energy-related impact of stress has received considerable attention in the past few years, the critical importance of the specialized cellular hubs called mitochondrial-endoplasmic reticulum (ER) associated membranes (MAMs) in stress responses, remains to be elucidated. Combining cutting-edge approaches, the aMUST project will shed light on this crucial biological question. Accordingly, intracranial lenses insertion of the mini endoscope in stress-vulnerable brain regions will be used to allow the study of in vivo mitochondrial calcium dynamics during behavioral experiments. 3D electron microscopy, protein ligase assay and BioID in vivo proteomics will allow to determine composition in MAMs structures and which protein interactions are altered during stress. The use of transgenic animals, compounds that change MAMs proteins function and alleviate ER-stress will be used to prevent possible modifications that cause vulnerability to stress. Therefore, aMUST project outcomes will unveil the MAMs-related mechanisms needed to open new therapeutic avenues to promote resilience to stress.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- natural sciences physical sciences optics microscopy electron microscopy
- medical and health sciences basic medicine pathology
- medical and health sciences basic medicine physiology homeostasis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2019
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1015 LAUSANNE
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.