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Super Time-resolved Fluorescence Anisotropy with Switchable States

Project description

The lights never go down on the best protein show in town

Proteins are the main enablers of practically every process in a cell and between cells, directly or indirectly. Their complex 3D structures play a fundamental role in their dynamic interactions with the molecules around them, and that conformation changes in time and according to need. The ability to characterise protein-protein interactions and protein conformational changes in time is critical to our understanding of the body in health and disease. Fluorescence anisotropy does just that, measuring changes in absorption and emission from a fluorophore to detect the changing orientation of a molecule in space. However, the 'video' is shut down when the fluorescence lifetime is reached – very quickly. The EU-funded STARSS project plans to revolutionise the technique with reversibly switchable fluorescent transitions that will keep the coverage coming with practically no upper limit on molecular size.


Net EU contribution
€ 191 852,16
Brinellvagen 8
100 44 Stockholm

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Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00