Objective
Cell division is a fundamental process that allows the multiplication of all bacteria. Although this mechanism is essential for their survival, it is one of the least understood processes in bacterial cell biology. Understanding the molecular function of different factors implicated in this key event of the bacterial cell cycle is essential. Furthermore the characterization of cell division machinery will open up new opportunities in bioengineering and development of novel therapeutic and antibacterial agents.
During the past ten years, genetic approaches as well as major improvements in cytological and immunofluorescence techniques generated a wealth of data on the localization and recruitment of cell division proteins to the septum. However, specific protein interactions and complex formation have not been studied in great detail. This research project is directed at elucidating the interactions and communication between cell division proteins in Gram-negative bacteria, thus initiating a new dimension to the study of cell division.
The first phase of the project will emphasize the use of biochemistry to define direct interactions between proteins assembled at the septum and to identify and characterize new cell division components. During the second phase, a n innovative and powerful genetic tool based on bacterial double hybrid system will be developed in order to validate, in an in vivo context, protein interactions and the new partners unveiled by genetic and biochemical approaches. This project will contribute to the development of a competitive high impact field in Europe by significantly extending our knowledge on cell division process and by combining classical and innovative approaches.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences cell biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-6
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.