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Factors driving mother-to-infant microbiota transfer

Project description

Microbiota transfer from mother to infant

Gut microbiota alterations have been linked to an increased risk of non-communicable diseases (NCDs) such as allergy, obesity and cardiovascular disease. Early microbial colonisation of the gastrointestinal tract (GIT) is essential for an optimal colonisation pattern. Transfer of microbes from mother to infant is believed to be a critical step in passing microbiota from one generation to another for the development of a healthy infant gut. The EU-funded MicroMI project aims to create a novel approach using available state-of-the-art methodologies to reveal the mechanisms underlying the host–microbe interaction in GIT maturation during early development. Moreover, MicroMI is adapting methods of modern sequencing technologies to gain knowledge on probiotic-related issues.


Human microbiota has vital effects on human health and physiology. Gut microbiota alteration has been linked to risk of non-communicable diseases (NCDs) as allergy, obesity and cardiovascular diseases. NCDs are increasing and account for more than 41 million people deaths per year (71% of all deaths globally), being more critical in infants. Early microbial colonization of the GIT is essential for an optimal health, thus, altered microbial colonization patterns have been linked to an increased risk of NCDs. Mother-to-infant transfer of microbes is believed to be a crucial opportunity to pass on IM from one generation to another, representing a pivotal step in the development of the early infant gut microbiota. Much research to date has addressed the impact of the environment on the microbiota composition, nowadays, is time to go further and to define this mechanism in a compositional, functional and metabolic level. An in-depth understanding of the effect of maternal IM in the early life and its long-term impact is urgently needed. The EU is promoting actions developing new dietary solutions to improve public health, therefore, MicroMI aims to make a novel approach by using state-of-the-art methodologies already established within the host institution (CSIC) to reveal the mechanisms underlying this host-microbe interaction in the GIT development and maturation in early life. MicroMI adapts methods based on cutting-edge sequencing technologies to gain knowledge on probiotic-related issues. This project will positively impact on the European society and economy. Within MicroMi, the applicant will perform state-of-the-art research, will promote science as a career and gender equality and she will establish an innovative translation multidisciplinary programme. Funding of this action will allow the research applicant to foster and share her skills and reinforce herself as a mature and independent professional, starting to forge a stable career.


Net EU contribution
€ 172 932,48
Calle serrano 117
28006 Madrid

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Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Other funding
€ 0,00