Project description DEENESFRITPL Microbiota transfer from mother to infant Gut microbiota alterations have been linked to an increased risk of non-communicable diseases (NCDs) such as allergy, obesity and cardiovascular disease. Early microbial colonisation of the gastrointestinal tract (GIT) is essential for an optimal colonisation pattern. Transfer of microbes from mother to infant is believed to be a critical step in passing microbiota from one generation to another for the development of a healthy infant gut. The EU-funded MicroMI project aims to create a novel approach using available state-of-the-art methodologies to reveal the mechanisms underlying the host–microbe interaction in GIT maturation during early development. Moreover, MicroMI is adapting methods of modern sequencing technologies to gain knowledge on probiotic-related issues. Show the project objective Hide the project objective Objective Human microbiota has vital effects on human health and physiology. Gut microbiota alteration has been linked to risk of non-communicable diseases (NCDs) as allergy, obesity and cardiovascular diseases. NCDs are increasing and account for more than 41 million people deaths per year (71% of all deaths globally), being more critical in infants. Early microbial colonization of the GIT is essential for an optimal health, thus, altered microbial colonization patterns have been linked to an increased risk of NCDs. Mother-to-infant transfer of microbes is believed to be a crucial opportunity to pass on IM from one generation to another, representing a pivotal step in the development of the early infant gut microbiota. Much research to date has addressed the impact of the environment on the microbiota composition, nowadays, is time to go further and to define this mechanism in a compositional, functional and metabolic level. An in-depth understanding of the effect of maternal IM in the early life and its long-term impact is urgently needed. The EU is promoting actions developing new dietary solutions to improve public health, therefore, MicroMI aims to make a novel approach by using state-of-the-art methodologies already established within the host institution (CSIC) to reveal the mechanisms underlying this host-microbe interaction in the GIT development and maturation in early life. MicroMI adapts methods based on cutting-edge sequencing technologies to gain knowledge on probiotic-related issues. This project will positively impact on the European society and economy. Within MicroMi, the applicant will perform state-of-the-art research, will promote science as a career and gender equality and she will establish an innovative translation multidisciplinary programme. Funding of this action will allow the research applicant to foster and share her skills and reinforce herself as a mature and independent professional, starting to forge a stable career. Fields of science medical and health scienceshealth sciencespublic healthmedical and health sciencesclinical medicinecardiologycardiovascular diseasesmedical and health sciencesclinical medicineallergologymedical and health sciencesbasic medicinephysiologymedical and health scienceshealth sciencesnutritionobesity Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2019 - Individual Fellowships Call for proposal H2020-MSCA-IF-2019 See other projects for this call Funding Scheme MSCA-IF-EF-ST - Standard EF Coordinator AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Net EU contribution € 172 932,48 Address Calle serrano 117 28006 Madrid Spain See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
